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DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod9

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod9 Module size 66 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 219870 OR10G9 olfactory receptor family 10 subfamily G member 9 26539 OR10H1 olfactory receptor family 10 subfamily H member 1 26538 OR10H2 olfactory receptor family 10 subfamily H member 2 26532 OR10H3 olfactory receptor family 10 subfamily H member 3 126541 OR10H4 olfactory receptor family 10 subfamily H member 4 441911 OR10J3 olfactory receptor family 10 subfamily J member 3 127385 OR10J5 olfactory receptor family 10 subfamily J member 5 391109 OR10K1 olfactory receptor family 10 subfamily K member 1 128360 OR10T2 olfactory receptor family 10 subfamily T member 2 392376 OR13C2 olfactory receptor family 13 subfamily C member 2 138805 OR13F1 olfactory receptor family 13 subfamily F member 1 392309 OR13J1 olfactory receptor family 13 subfamily J member 1 388761 OR14A2 olfactory receptor family 14 subfamily A member 2 343170 OR14K1 olfactory receptor family 14 subfamily K member 1 26189 OR1A2 olfactory receptor family 1 subfamily A member 2 347169 OR1B1 olfactory receptor family 1 subfamily B member 1 (gene/pseudogene) 4991 OR1D2 olfactory receptor family 1 subfamily D member 2 8388 OR1E2 olfactory receptor family 1 subfamily E member 2 347168 OR1J1 olfactory receptor family 1 subfamily J member 1 26219 OR1J4 olfactory receptor family 1 subfamily J member 4 392392 OR1K1 olfactory receptor family 1 subfamily K member 1 125963 OR1M1 olfactory receptor family 1 subfamily M member 1 138882 OR1N2 olfactory receptor family 1 subfamily N member 2 158131 OR1Q1 olfactory receptor family 1 subfamily Q member 1 393046 OR2A5 olfactory receptor family 2 subfamily A member 5 401427 OR2A7 olfactory receptor family 2 subfamily A member 7 144125 OR2AG1 olfactory receptor family 2 subfamily AG member 1 (gene/pseudogene) 121129 OR2AP1 olfactory receptor family 2 subfamily AP member 1 284521 OR2L13 olfactory receptor family 2 subfamily L member 13 391196 OR2M7 olfactory receptor family 2 subfamily M member 7 81318 OR4A5 olfactory receptor family 4 subfamily A member 5 219986 OR4D11 olfactory receptor family 4 subfamily D member 11 219983 OR4D6 olfactory receptor family 4 subfamily D member 6 81127 OR4K15 olfactory receptor family 4 subfamily K member 15 390436 OR4K17 olfactory receptor family 4 subfamily K member 17 283694 OR4N4 olfactory receptor family 4 subfamily N member 4 401667 OR51A2 olfactory receptor family 51 subfamily A member 2 81282 OR51G2 olfactory receptor family 51 subfamily G member 2 390063 OR51I1 olfactory receptor family 51 subfamily I member 1 390061 OR51Q1 olfactory receptor family 51 subfamily Q member 1 (gene/pseudogene) 143496 OR52B4 olfactory receptor family 52 subfamily B member 4 (gene/pseudogene) 390079 OR52E8 olfactory receptor family 52 subfamily E member 8 119679 OR52J3 olfactory receptor family 52 subfamily J member 3 120787 OR52W1 olfactory receptor family 52 subfamily W member 1 219982 OR5A1 olfactory receptor family 5 subfamily A member 1 390181 OR5AK2 olfactory receptor family 5 subfamily AK member 2 219447 OR5AS1 olfactory receptor family 5 subfamily AS member 1 390191 OR5B12 olfactory receptor family 5 subfamily B member 12 390190 OR5B2 olfactory receptor family 5 subfamily B member 2 219438 OR5D18 olfactory receptor family 5 subfamily D member 18 403274 OR5H15 olfactory receptor family 5 subfamily H member 15 282775 OR5J2 olfactory receptor family 5 subfamily J member 2 403277 OR5K3 olfactory receptor family 5 subfamily K member 3 219484 OR5M8 olfactory receptor family 5 subfamily M member 8 390162 OR5M9 olfactory receptor family 5 subfamily M member 9 120065 OR5P2 olfactory receptor family 5 subfamily P member 2 120066 OR5P3 olfactory receptor family 5 subfamily P member 3 135946 OR6B1 olfactory receptor family 6 subfamily B member 1 150681 OR6B3 olfactory receptor family 6 subfamily B member 3 283365 OR6C6 olfactory receptor family 6 subfamily C member 6 403282 OR6C65 olfactory receptor family 6 subfamily C member 65 403284 OR6C68 olfactory receptor family 6 subfamily C member 68 79549 OR6J1 olfactory receptor family 6 subfamily J member 1 (gene/pseudogene) 391112 OR6Y1 olfactory receptor family 6 subfamily Y member 1 26658 OR7C2 olfactory receptor family 7 subfamily C member 2 390152 OR8H3 olfactory receptor family 8 subfamily H member 3

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

Most specific annotations for this module

Coeff.1 P-value.2 Source.3 Term.4 Class.5 1.11e-01 8.07e-106 Reactome Olfactory Signaling Pathway Signal Transduction 7.08e-02 5.92e-09 GO G-protein coupled serotonin receptor signaling pathway biological_process 1.15e-02 2.30e-24 GO odorant binding molecular_function 6.54e-03 3.09e-97 Reactome G alpha (s) signalling events Signal Transduction

¹Regression coefficient

²Fisher’s exact test nominal P-value

³Annotation source (Reactome, GO biological process (BP), molecular function (MF) and cellular component (CC))

⁴GO category or Reactome pathway

⁵High-level branch of annotation tree

Gene membership

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 0.00e+00 0.00e+00 detection of stimulus involved in sensory perception 0.00e+00 0.00e+00 detection of chemical stimulus involved in sensory perception 0.00e+00 0.00e+00 detection of chemical stimulus 0.00e+00 0.00e+00 sensory perception of chemical stimulus 0.00e+00 0.00e+00 sensory perception of smell 0.00e+00 0.00e+00 detection of stimulus 0.00e+00 0.00e+00 detection of chemical stimulus involved in sensory perception of smell 0.00e+00 0.00e+00 G-protein coupled receptor activity 0.00e+00 0.00e+00 olfactory receptor activity 2.97e-18 2.12e-15 odorant binding 3.37e-10 1.94e-07 neurotransmitter receptor activity 6.77e-09 3.16e-06 G-protein coupled serotonin receptor activity 4.38e-06 1.83e-03 serotonin receptor signaling pathway 3.68e-03 4.74e-01 dopamine binding 3.68e-03 4.74e-01 dopamine neurotransmitter receptor activity, coupled via Gi/Go 7.79e-03 9.47e-01 negative regulation of voltage-gated calcium channel activity 7.79e-03 9.47e-01 negative regulation of synaptic transmission, glutamatergic 7.79e-03 9.47e-01 adenylate cyclase-inhibiting dopamine receptor signaling pathway 7.79e-03 9.47e-01 negative regulation of cytosolic calcium ion concentration 7.80e-03 9.47e-01 negative regulation of adenylate cyclase activity

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 0e+00 0e+00 OLFACTORY SIGNALING PATHWAY

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)