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DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod369

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod369 Module size 3 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 90693 CCDC126 coiled-coil domain containing 126 8263 F8A1 coagulation factor VIII associated 1 116211 TM4SF19 transmembrane 4 L six family member 19

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

Most specific annotations for this module

Coeff.1 P-value.2 Source.3 Term.4 Class.5 1.29e-01 6.63e-11 GO peptidyl-proline hydroxylation to 4-hydroxy-L-proline biological_process 6.18e-02 1.95e-10 GO oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen molecular_function

¹Regression coefficient

²Fisher’s exact test nominal P-value

³Annotation source (Reactome, GO biological process (BP), molecular function (MF) and cellular component (CC))

⁴GO category or Reactome pathway

⁵High-level branch of annotation tree

Gene membership

All enriched annotations