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DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod363

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod363 Module size 4 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 5537 PPP6C protein phosphatase 6 catalytic subunit 22870 PPP6R1 protein phosphatase 6 regulatory subunit 1 9701 PPP6R2 protein phosphatase 6 regulatory subunit 2 55291 PPP6R3 protein phosphatase 6 regulatory subunit 3

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

No specific annotations were found for this module

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 7.05e-07 3.46e-04 COPII vesicle coating 7.07e-07 3.46e-04 COPII-coated vesicle budding 7.08e-07 3.47e-04 vesicle targeting, to, from or within Golgi 1.06e-06 5.01e-04 vesicle targeting 1.53e-06 7.03e-04 membrane budding 4.15e-06 1.74e-03 ER to Golgi vesicle-mediated transport 1.14e-05 4.36e-03 establishment of vesicle localization 1.34e-05 5.03e-03 vesicle localization 1.97e-05 7.08e-03 regulation of phosphoprotein phosphatase activity 2.62e-05 9.11e-03 establishment of organelle localization 3.39e-05 1.14e-02 organelle localization 3.48e-05 1.17e-02 vesicle organization 4.82e-05 1.55e-02 Golgi vesicle transport 6.43e-05 1.41e-02 protein phosphatase binding 7.92e-05 2.39e-02 regulation of protein dephosphorylation 9.52e-05 1.98e-02 phosphatase binding 1.79e-04 4.77e-02 regulation of phosphatase activity 3.19e-04 7.74e-02 regulation of dephosphorylation 1.05e-03 1.52e-01 Golgi membrane 1.32e-02 1.00e+00 protein serine/threonine phosphatase activity

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)