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DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod356

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod356 Module size 3 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 63978 PRDM14 PR/SET domain 14 7547 ZIC3 Zic family member 3 84891 ZSCAN10 zinc finger and SCAN domain containing 10

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

No specific annotations were found for this module

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 3.46e-07 1.79e-04 somatic stem cell population maintenance 1.55e-06 7.12e-04 stem cell population maintenance 1.95e-03 3.34e-01 negative regulation of fibroblast growth factor receptor signaling pathway 1.95e-03 3.34e-01 positive regulation of stem cell population maintenance 3.89e-03 5.71e-01 inner cell mass cell differentiation 3.89e-03 5.71e-01 inner cell mass cell fate commitment 3.89e-03 5.71e-01 dosage compensation by inactivation of X chromosome 3.89e-03 5.71e-01 positive regulation of flagellated sperm motility 3.89e-03 5.71e-01 germ-line stem cell population maintenance 5.83e-03 7.72e-01 determination of liver left/right asymmetry 5.83e-03 7.72e-01 determination of digestive tract left/right asymmetry 5.83e-03 7.72e-01 determination of pancreatic left/right asymmetry 5.83e-03 7.72e-01 histone arginine methylation 5.83e-03 7.72e-01 dosage compensation 5.83e-03 7.72e-01 peptidyl-arginine methylation 5.83e-03 7.72e-01 regulation of DNA methylation 5.84e-03 7.72e-01 blastocyst formation 7.77e-03 9.47e-01 regulation of fibroblast growth factor receptor signaling pathway 7.77e-03 9.47e-01 regulation of stem cell population maintenance 9.71e-03 1.00e+00 homeostasis of number of cells within a tissue

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Mouse mutant phenotypes

P-value1 FDR2 Term 5.02e-04 6.07e-01 decreased rib number 3.75e-03 1.00e+00 abnormal lung position or orientation 3.76e-03 1.00e+00 abnormal anterior primitive streak morphology 3.76e-03 1.00e+00 small allantois 5.45e-03 1.00e+00 partial preweaning lethality 5.63e-03 1.00e+00 abnormal left-right axis symmetry of the somites 5.63e-03 1.00e+00 lung situs inversus 5.63e-03 1.00e+00 absent germ cells 5.64e-03 1.00e+00 rostral-caudal axis duplication 7.49e-03 1.00e+00 abnormal primordial germ cell morphology 7.50e-03 1.00e+00 abnormal primitive streak elongation 7.50e-03 1.00e+00 situs ambiguus 7.50e-03 1.00e+00 split notochord 7.51e-03 1.00e+00 abnormal motile primary cilium morphology 7.51e-03 1.00e+00 abnormal basal ganglion morphology 9.37e-03 1.00e+00 cranioschisis 9.37e-03 1.00e+00 abnormal anterior visceral endoderm morphology 9.37e-03 1.00e+00 premaxilla hypoplasia 9.42e-03 1.00e+00 abnormal endoderm development 1.12e-02 1.00e+00 absent primitive node

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)