Back to main page

DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod31

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod31 Module size 98 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 5324 PLAG1 PLAG1 zinc finger 100128927 ZBTB42 zinc finger and BTB domain containing 42 84878 ZBTB45 zinc finger and BTB domain containing 45 201501 ZBTB7C zinc finger and BTB domain containing 7C 728116 ZBTB8B zinc finger and BTB domain containing 8B 57677 ZFP14 ZFP14 zinc finger protein 140612 ZFP28 ZFP28 zinc finger protein 286128 ZFP41 ZFP41 zinc finger protein 7543 ZFX zinc finger protein X-linked 7544 ZFY zinc finger protein Y-linked 23619 ZIM2 zinc finger imprinted 2 7695 ZNF136 zinc finger protein 136 7701 ZNF142 zinc finger protein 142 7710 ZNF154 zinc finger protein 154 169841 ZNF169 zinc finger protein 169 10520 ZNF211 zinc finger protein 211 7760 ZNF213 zinc finger protein 213 7762 ZNF215 zinc finger protein 215 7673 ZNF222 zinc finger protein 222 7769 ZNF226 zinc finger protein 226 7772 ZNF229 zinc finger protein 229 7773 ZNF230 zinc finger protein 230 10780 ZNF234 zinc finger protein 234 9310 ZNF235 zinc finger protein 235 7776 ZNF236 zinc finger protein 236 219749 ZNF25 zinc finger protein 25 10172 ZNF256 zinc finger protein 256 7574 ZNF26 zinc finger protein 26 10781 ZNF266 zinc finger protein 266 8427 ZNF282 zinc finger protein 282 57335 ZNF286A zinc finger protein 286A 57567 ZNF319 zinc finger protein 319 388569 ZNF324B zinc finger protein 324B 79673 ZNF329 zinc finger protein 329 26152 ZNF337 zinc finger protein 337 80778 ZNF34 zinc finger protein 34 30832 ZNF354C zinc finger protein 354C 195828 ZNF367 zinc finger protein 367 7587 ZNF37A zinc finger protein 37A 84911 ZNF382 zinc finger protein 382 155054 ZNF425 zinc finger protein 425 7594 ZNF43 zinc finger protein 43 170959 ZNF431 zinc finger protein 431 90594 ZNF439 zinc finger protein 439 126068 ZNF441 zinc finger protein 441 285676 ZNF454 zinc finger protein 454 84627 ZNF469 zinc finger protein 469 83744 ZNF484 zinc finger protein 484 57615 ZNF492 zinc finger protein 492 115560 ZNF501 zinc finger protein 501 22847 ZNF507 zinc finger protein 507 84874 ZNF514 zinc finger protein 514 147807 ZNF524 zinc finger protein 524 163255 ZNF540 zinc finger protein 540 125919 ZNF543 zinc finger protein 543 339327 ZNF546 zinc finger protein 546 90233 ZNF551 zinc finger protein 551 148156 ZNF558 zinc finger protein 558 93134 ZNF561 zinc finger protein 561 147929 ZNF565 zinc finger protein 565 148266 ZNF569 zinc finger protein 569 126231 ZNF573 zinc finger protein 573 51545 ZNF581 zinc finger protein 581 199704 ZNF585A zinc finger protein 585A 162966 ZNF600 zinc finger protein 600 100289635 ZNF605 zinc finger protein 605 81856 ZNF611 zinc finger protein 611 80110 ZNF614 zinc finger protein 614 284370 ZNF615 zinc finger protein 615 199777 ZNF626 zinc finger protein 626 23361 ZNF629 zinc finger protein 629 127665 ZNF648 zinc finger protein 648 389114 ZNF662 zinc finger protein 662 79862 ZNF669 zinc finger protein 669 7617 ZNF66P zinc finger protein 66 171392 ZNF675 zinc finger protein 675 7620 ZNF69 zinc finger protein 69 51058 ZNF691 zinc finger protein 691 286075 ZNF707 zinc finger protein 707 163051 ZNF709 zinc finger protein 709 58491 ZNF71 zinc finger protein 71 374655 ZNF710 zinc finger protein 710 148206 ZNF714 zinc finger protein 714 442319 ZNF727 zinc finger protein 727 283337 ZNF740 zinc finger protein 740 7626 ZNF75D zinc finger protein 75D 54989 ZNF770 zinc finger protein 770 51333 ZNF771 zinc finger protein 771 27153 ZNF777 zinc finger protein 777 390927 ZNF793 zinc finger protein 793 126017 ZNF813 zinc finger protein 813 283933 ZNF843 zinc finger protein 843 162993 ZNF846 zinc finger protein 846 81931 ZNF93 zinc finger protein 93 54993 ZSCAN2 zinc finger and SCAN domain containing 2 201516 ZSCAN4 zinc finger and SCAN domain containing 4 646698 ZSCAN5D zinc finger and SCAN domain containing 5D pseudogene 158586 ZXDB zinc finger X-linked duplicated B

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

Most specific annotations for this module

Coeff.1 P-value.2 Source.3 Term.4 Class.5 4.34e-02 3.43e-71 Reactome Generic Transcription Pathway Gene expression (Transcription) 8.10e-03 5.90e-68 Reactome RNA Polymerase II Transcription Gene expression (Transcription)

¹Regression coefficient

²Fisher’s exact test nominal P-value

³Annotation source (Reactome, GO biological process (BP), molecular function (MF) and cellular component (CC))

⁴GO category or Reactome pathway

⁵High-level branch of annotation tree

Gene membership

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 1.55e-05 5.73e-03 regulation of transcription regulatory region DNA binding 5.91e-05 1.85e-02 negative regulation of transcription from RNA polymerase II promoter 4.41e-04 1.01e-01 regulation of DNA binding 6.22e-04 1.34e-01 negative regulation of DNA metabolic process 7.59e-04 1.58e-01 negative regulation of sequence-specific DNA binding transcription factor activity 8.44e-04 1.33e-01 transcription regulatory region DNA binding 8.72e-04 1.37e-01 regulatory region DNA binding 1.84e-03 2.62e-01 RNA polymerase II transcription factor activity, sequence-specific DNA binding 1.95e-03 3.34e-01 negative regulation of mitotic recombination 1.95e-03 3.34e-01 negative regulation of transcription regulatory region DNA binding 1.95e-03 3.34e-01 negative regulation of interleukin-1-mediated signaling pathway 2.14e-03 2.77e-01 nuclear chromosome, telomeric region 2.76e-03 4.42e-01 regulation of binding 3.89e-03 5.71e-01 regulation of RNA polymerase II regulatory region sequence-specific DNA binding 3.89e-03 5.71e-01 regulation of mitotic recombination 3.89e-03 5.71e-01 regulation of interleukin-1-mediated signaling pathway 3.89e-03 5.71e-01 positive regulation of glial cell proliferation 3.90e-03 5.71e-01 negative regulation of JUN kinase activity 5.84e-03 7.72e-01 bone resorption 5.84e-03 7.72e-01 negative regulation of osteoclast differentiation

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 0e+00 0e+00 GENERIC TRANSCRIPTION PATHWAY

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Mouse mutant phenotypes

P-value1 FDR2 Term 1.87e-03 1e+00 abnormal embryonic growth/weight/body size 1.87e-03 1e+00 abnormal seminal vesicle morphology 1.87e-03 1e+00 small prostate gland ventral lobe 3.75e-03 1e+00 abnormal postnatal growth/weight/body size 3.75e-03 1e+00 decreased embryo weight 3.76e-03 1e+00 decreased hematopoietic stem cell number 5.62e-03 1e+00 decreased mature ovarian follicle number 5.62e-03 1e+00 decreased seminal vesicle weight 7.48e-03 1e+00 decreased germ cell number 7.49e-03 1e+00 delayed eyelid opening 9.40e-03 1e+00 abnormal fertility/fecundity 1.12e-02 1e+00 decreased primordial germ cell number 1.31e-02 1e+00 decreased oocyte number 1.31e-02 1e+00 increased chromosomal stability 2.62e-02 1e+00 abnormal extraembryonic tissue morphology 2.71e-02 1e+00 increased mean corpuscular volume

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)