Back to main page

DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod278

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod278 Module size 38 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 390093 OR10A6 olfactory receptor family 10 subfamily A member 6 (gene/pseudogene) 121130 OR10P1 olfactory receptor family 10 subfamily P member 1 219960 OR10Q1 olfactory receptor family 10 subfamily Q member 1 81341 OR10W1 olfactory receptor family 10 subfamily W member 1 138803 OR13C3 olfactory receptor family 13 subfamily C member 3 286362 OR13C9 olfactory receptor family 13 subfamily C member 9 126370 OR1I1 olfactory receptor family 1 subfamily I member 1 138883 OR1N1 olfactory receptor family 1 subfamily N member 1 392138 OR2A25 olfactory receptor family 2 subfamily A member 25 391191 OR2AK2 olfactory receptor family 2 subfamily AK member 2 341152 OR2AT4 olfactory receptor family 2 subfamily AT member 4 4993 OR2C1 olfactory receptor family 2 subfamily C member 1 135948 OR2F2 olfactory receptor family 2 subfamily F member 2 81466 OR2L5 olfactory receptor family 2 subfamily L member 5 127077 OR2T11 olfactory receptor family 2 subfamily T member 11 (gene/pseudogene) 391195 OR2T33 olfactory receptor family 2 subfamily T member 33 343172 OR2T8 olfactory receptor family 2 subfamily T member 8 219432 OR4C6 olfactory receptor family 4 subfamily C member 6 390199 OR4D9 olfactory receptor family 4 subfamily D member 9 79544 OR4K1 olfactory receptor family 4 subfamily K member 1 79317 OR4K5 olfactory receptor family 4 subfamily K member 5 81300 OR4P4 olfactory receptor family 4 subfamily P member 4 79345 OR51B2 olfactory receptor family 51 subfamily B member 2 (gene/pseudogene) 390038 OR51D1 olfactory receptor family 51 subfamily D member 1 256892 OR51F1 olfactory receptor family 51 subfamily F member 1 (gene/pseudogene) 119694 OR51F2 olfactory receptor family 51 subfamily F member 2 119682 OR51L1 olfactory receptor family 51 subfamily L member 1 390075 OR52N5 olfactory receptor family 52 subfamily N member 5 338675 OR5AP2 olfactory receptor family 5 subfamily AP member 2 403278 OR5K4 olfactory receptor family 5 subfamily K member 4 390323 OR6C75 olfactory receptor family 6 subfamily C member 75 343169 OR6F1 olfactory receptor family 6 subfamily F member 1 391114 OR6K3 olfactory receptor family 6 subfamily K member 3 128371 OR6K6 olfactory receptor family 6 subfamily K member 6 128372 OR6N1 olfactory receptor family 6 subfamily N member 1 125962 OR7G1 olfactory receptor family 7 subfamily G member 1 390883 OR7G3 olfactory receptor family 7 subfamily G member 3 390275 OR8A1 olfactory receptor family 8 subfamily A member 1

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

Most specific annotations for this module

Coeff.1 P-value.2 Source.3 Term.4 Class.5 5.77e-02 1.16e-62 Reactome Olfactory Signaling Pathway Signal Transduction 1.96e-03 8.58e-58 Reactome G alpha (s) signalling events Signal Transduction

¹Regression coefficient

²Fisher’s exact test nominal P-value

³Annotation source (Reactome, GO biological process (BP), molecular function (MF) and cellular component (CC))

⁴GO category or Reactome pathway

⁵High-level branch of annotation tree

Gene membership

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 0.00e+00 0.00e+00 sensory perception of chemical stimulus 0.00e+00 0.00e+00 detection of stimulus involved in sensory perception 0.00e+00 0.00e+00 detection of chemical stimulus involved in sensory perception 0.00e+00 0.00e+00 detection of chemical stimulus 0.00e+00 0.00e+00 sensory perception of smell 0.00e+00 0.00e+00 detection of stimulus 0.00e+00 0.00e+00 detection of chemical stimulus involved in sensory perception of smell 0.00e+00 0.00e+00 G-protein coupled receptor activity 0.00e+00 0.00e+00 olfactory receptor activity 5.68e-06 1.56e-03 odorant binding

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 0e+00 0e+00 OLFACTORY SIGNALING PATHWAY

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)