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DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod273

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod273 Module size 80 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 341276 OR10A2 olfactory receptor family 10 subfamily A member 2 121364 OR10A7 olfactory receptor family 10 subfamily A member 7 121275 OR10AD1 olfactory receptor family 10 subfamily AD member 1 26534 OR10G2 olfactory receptor family 10 subfamily G member 2 390264 OR10G4 olfactory receptor family 10 subfamily G member 4 390265 OR10G7 olfactory receptor family 10 subfamily G member 7 219869 OR10G8 olfactory receptor family 10 subfamily G member 8 391107 OR10K2 olfactory receptor family 10 subfamily K member 2 343406 OR10R2 olfactory receptor family 10 subfamily R member 2 390442 OR11H4 olfactory receptor family 11 subfamily H member 4 138799 OR13C5 olfactory receptor family 13 subfamily C member 5 127066 OR14C36 olfactory receptor family 14 subfamily C member 36 8387 OR1E1 olfactory receptor family 1 subfamily E member 1 26740 OR1J2 olfactory receptor family 1 subfamily J member 2 254973 OR1L4 olfactory receptor family 1 subfamily L member 4 392390 OR1L6 olfactory receptor family 1 subfamily L member 6 138881 OR1L8 olfactory receptor family 1 subfamily L member 8 442361 OR2A2 olfactory receptor family 2 subfamily A member 2 79541 OR2A4 olfactory receptor family 2 subfamily A member 4 127608 OR2AJ1 olfactory receptor family 2 subfamily AJ member 1 127623 OR2B11 olfactory receptor family 2 subfamily B member 11 26212 OR2B6 olfactory receptor family 2 subfamily B member 6 120776 OR2D2 olfactory receptor family 2 subfamily D member 2 81469 OR2G3 olfactory receptor family 2 subfamily G member 3 391211 OR2G6 olfactory receptor family 2 subfamily G member 6 391192 OR2L3 olfactory receptor family 2 subfamily L member 3 391194 OR2M2 olfactory receptor family 2 subfamily M member 2 26696 OR2T1 olfactory receptor family 2 subfamily T member 1 127069 OR2T10 olfactory receptor family 2 subfamily T member 10 343563 OR2T29 olfactory receptor family 2 subfamily T member 29 127068 OR2T34 olfactory receptor family 2 subfamily T member 34 403244 OR2T35 olfactory receptor family 2 subfamily T member 35 285659 OR2V2 olfactory receptor family 2 subfamily V member 2 343171 OR2W3 olfactory receptor family 2 subfamily W member 3 4994 OR3A1 olfactory receptor family 3 subfamily A member 1 119765 OR4B1 olfactory receptor family 4 subfamily B member 1 124538 OR4D2 olfactory receptor family 4 subfamily D member 2 219875 OR4D5 olfactory receptor family 4 subfamily D member 5 441308 OR4F21 olfactory receptor family 4 subfamily F member 21 390648 OR4F6 olfactory receptor family 4 subfamily F member 6 390433 OR4K13 olfactory receptor family 4 subfamily K member 13 390431 OR4K2 olfactory receptor family 4 subfamily K member 2 390538 OR4M2 olfactory receptor family 4 subfamily M member 2 390437 OR4N5 olfactory receptor family 4 subfamily N member 5 390113 OR4X1 olfactory receptor family 4 subfamily X member 1 (gene/pseudogene) 79324 OR51G1 olfactory receptor family 51 subfamily G member 1 (gene/pseudogene) 390054 OR52A5 olfactory receptor family 52 subfamily A member 5 390066 OR52D1 olfactory receptor family 52 subfamily D member 1 119678 OR52E2 olfactory receptor family 52 subfamily E member 2 390081 OR52E4 olfactory receptor family 52 subfamily E member 4 390067 OR52H1 olfactory receptor family 52 subfamily H member 1 143502 OR52I1 olfactory receptor family 52 subfamily I member 2 143502 OR52I2 olfactory receptor family 52 subfamily I member 2 119774 OR52K2 olfactory receptor family 52 subfamily K member 2 79473 OR52N1 olfactory receptor family 52 subfamily N member 1 390072 OR52N4 olfactory receptor family 52 subfamily N member 4 (gene/pseudogene) 119695 OR52R1 olfactory receptor family 52 subfamily R member 1 (gene/pseudogene) 120793 OR56A4 olfactory receptor family 56 subfamily A member 4 387748 OR56B1 olfactory receptor family 56 subfamily B member 1 390195 OR5AN1 olfactory receptor family 5 subfamily AN member 1 219968 OR5B21 olfactory receptor family 5 subfamily B member 21 392391 OR5C1 olfactory receptor family 5 subfamily C member 1 390142 OR5D13 olfactory receptor family 5 subfamily D member 13 (gene/pseudogene) 219436 OR5D14 olfactory receptor family 5 subfamily D member 14 26341 OR5H1 olfactory receptor family 5 subfamily H member 1 402135 OR5K2 olfactory receptor family 5 subfamily K member 2 219479 OR5R1 olfactory receptor family 5 subfamily R member 1 (gene/pseudogene) 8590 OR6A2 olfactory receptor family 6 subfamily A member 2 390321 OR6C1 olfactory receptor family 6 subfamily C member 1 341418 OR6C4 olfactory receptor family 6 subfamily C member 4 81448 OR6K2 olfactory receptor family 6 subfamily K member 2 219952 OR6Q1 olfactory receptor family 6 subfamily Q member 1 (gene/pseudogene) 162998 OR7D2 olfactory receptor family 7 subfamily D member 2 26648 OR7E24 olfactory receptor family 7 subfamily E member 24 26595 OR8B2 olfactory receptor family 8 subfamily B member 2 283159 OR8D1 olfactory receptor family 8 subfamily D member 1 338662 OR8D4 olfactory receptor family 8 subfamily D member 4 81168 OR8J3 olfactory receptor family 8 subfamily J member 3 219453 OR8K5 olfactory receptor family 8 subfamily K member 5 219954 OR9I1 olfactory receptor family 9 subfamily I member 1

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

Most specific annotations for this module

Coeff.1 P-value.2 Source.3 Term.4 Class.5 1.45e-01 5.52e-133 Reactome Olfactory Signaling Pathway Signal Transduction 1.08e-02 3.15e-122 Reactome G alpha (s) signalling events Signal Transduction

¹Regression coefficient

²Fisher’s exact test nominal P-value

³Annotation source (Reactome, GO biological process (BP), molecular function (MF) and cellular component (CC))

⁴GO category or Reactome pathway

⁵High-level branch of annotation tree

Gene membership

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 0.00e+00 0.00e+00 sensory perception of chemical stimulus 0.00e+00 0.00e+00 detection of stimulus involved in sensory perception 0.00e+00 0.00e+00 detection of chemical stimulus involved in sensory perception 0.00e+00 0.00e+00 detection of chemical stimulus 0.00e+00 0.00e+00 sensory perception of smell 0.00e+00 0.00e+00 detection of stimulus 0.00e+00 0.00e+00 detection of chemical stimulus involved in sensory perception of smell 0.00e+00 0.00e+00 G-protein coupled receptor activity 0.00e+00 0.00e+00 olfactory receptor activity 6.31e-16 4.42e-13 odorant binding 3.90e-04 6.76e-02 neurotransmitter receptor activity 3.68e-03 4.74e-01 dopamine binding 3.68e-03 4.74e-01 dopamine neurotransmitter receptor activity, coupled via Gi/Go 5.30e-03 6.43e-01 dopamine neurotransmitter receptor activity 5.48e-03 5.97e-01 mitotic spindle midzone 5.48e-03 5.97e-01 mitotic spindle pole 5.48e-03 5.97e-01 Flemming body 5.85e-03 7.72e-01 negative regulation of voltage-gated calcium channel activity 5.85e-03 7.72e-01 negative regulation of synaptic transmission, glutamatergic 7.79e-03 9.47e-01 adenylate cyclase-inhibiting dopamine receptor signaling pathway

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 0e+00 0e+00 OLFACTORY SIGNALING PATHWAY

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)