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DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod257

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod257 Module size 41 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 115 ADCY9 adenylate cyclase 9 154 ADRB2 adrenoceptor beta 2 181 AGRP agouti related neuropeptide 81573 ANKRD13C ankyrin repeat domain 13C 434 ASIP agouti signaling protein 26033 ATRNL1 attractin like 1 796 CALCA calcitonin related polypeptide alpha 10203 CALCRL calcitonin receptor like receptor 50632 CALY calcyon neuron specific vesicular protein 91057 CCDC34 coiled-coil domain containing 34 83539 CHST9 carbohydrate sulfotransferase 9 27151 CPAMD8 C3 and PZP like, alpha-2-macroglobulin domain containing 8 1393 CRHBP corticotropin releasing hormone binding protein 1394 CRHR1 corticotropin releasing hormone receptor 1 1638 DCT dopachrome tautomerase 51738 GHRL ghrelin and obestatin prepropeptide 2778 GNAS GNAS complex locus 2782 GNB1 G protein subunit beta 1 139760 GPR119 G protein-coupled receptor 119 54112 GPR88 G protein-coupled receptor 88 9737 GPRASP1 G protein-coupled receptor associated sorting protein 1 114928 GPRASP2 G protein-coupled receptor associated sorting protein 2 56246 MRAP melanocortin 2 receptor accessory protein 112609 MRAP2 melanocortin 2 receptor accessory protein 2 259249 MRGPRX1 MAS related GPR family member X1 338557 O3FAR1 free fatty acid receptor 4 611 OPN1SW opsin 1, short wave sensitive 6490 PMEL premelanosome protein 10267 RAMP1 receptor activity modifying protein 1 10266 RAMP2 receptor activity modifying protein 2 10268 RAMP3 receptor activity modifying protein 3 6019 RLN2 relaxin 2 59350 RXFP1 relaxin family peptide receptor 1 122042 RXFP2 relaxin family peptide receptor 2 6344 SCTR secretin receptor 1318 SLC31A2 solute carrier family 31 member 2 83756 TAS1R3 taste 1 receptor member 3 7306 TYRP1 tyrosinase related protein 1 7349 UCN urocortin 29151 UCN2 urocortin 114131 UCN3 urocortin 3

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

Most specific annotations for this module

Coeff.1 P-value.2 Source.3 Term.4 Class.5 2.45e-01 1.50e-05 Reactome Melanin biosynthesis Metabolism 2.42e-01 4.32e-08 GO adrenomedullin receptor signaling pathway biological_process 1.62e-01 1.16e-11 Reactome Calcitonin-like ligand receptors Signal Transduction 1.54e-01 6.01e-07 Reactome Relaxin receptors Signal Transduction 9.90e-02 1.11e-08 GO melanin biosynthetic process biological_process 8.98e-02 1.28e-06 GO adult feeding behavior biological_process 6.66e-02 6.66e-14 GO hormone-mediated signaling pathway biological_process 4.57e-02 7.71e-21 Reactome Class B/2 (Secretin family receptors) Signal Transduction 1.87e-02 2.64e-18 GO adenylate cyclase-activating G-protein coupled receptor signaling pathway biological_process 8.70e-03 2.23e-04 GO adenylate cyclase-activating dopamine receptor signaling pathway biological_process 6.67e-03 8.91e-09 GO activation of adenylate cyclase activity biological_process 2.38e-04 1.02e-05 GO melanosome organization biological_process

¹Regression coefficient

²Fisher’s exact test nominal P-value

³Annotation source (Reactome, GO biological process (BP), molecular function (MF) and cellular component (CC))

⁴GO category or Reactome pathway

⁵High-level branch of annotation tree

Gene membership

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 0.00e+00 0.00e+00 positive regulation of cAMP biosynthetic process 0.00e+00 0.00e+00 regulation of cAMP metabolic process 0.00e+00 0.00e+00 regulation of cAMP biosynthetic process 0.00e+00 0.00e+00 positive regulation of cAMP metabolic process 0.00e+00 0.00e+00 positive regulation of cyclic nucleotide metabolic process 0.00e+00 0.00e+00 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 0.00e+00 0.00e+00 adenylate cyclase-modulating G-protein coupled receptor signaling pathway 0.00e+00 0.00e+00 adenylate cyclase-activating G-protein coupled receptor signaling pathway 0.00e+00 0.00e+00 G-protein coupled receptor binding 0.00e+00 0.00e+00 neuropeptide receptor binding 4.46e-08 1.81e-05 corticotropin-releasing hormone receptor 2 binding 4.93e-08 1.99e-05 hormone activity 5.05e-08 2.99e-05 feeding behavior 8.73e-08 3.39e-05 peptide hormone receptor binding 1.32e-07 7.31e-05 female pregnancy 1.36e-07 7.51e-05 melanin biosynthetic process 1.89e-07 6.92e-05 type 3 melanocortin receptor binding 1.89e-07 6.92e-05 type 4 melanocortin receptor binding 1.91e-07 1.03e-04 melanin metabolic process 4.14e-07 1.41e-04 G-protein coupled receptor activity

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 0.00e+00 0.00e+00 GPCR LIGAND BINDING 0.00e+00 0.00e+00 G ALPHA S SIGNALLING EVENTS 0.00e+00 0.00e+00 G ALPHA S SIGNALLING EVENTS 3.71e-10 9.53e-08 CLASS B 2 SECRETIN FAMILY RECEPTORS 3.94e-10 1.35e-07 CLASS B 2 SECRETIN FAMILY RECEPTORS 4.23e-05 5.74e-03 INTEGRATION OF ENERGY METABOLISM 4.35e-05 7.38e-03 INTEGRATION OF ENERGY METABOLISM 5.67e-05 9.36e-03 CLASS A1 RHODOPSIN LIKE RECEPTORS 2.25e-04 2.64e-02 REGULATION OF INSULIN SECRETION 2.53e-04 3.53e-02 REGULATION OF INSULIN SECRETION 2.56e-04 2.97e-02 GLUCAGON TYPE LIGAND RECEPTORS 5.11e-04 6.55e-02 GLUCAGON SIGNALING IN METABOLIC REGULATION 5.24e-04 6.70e-02 GLUCAGON TYPE LIGAND RECEPTORS 5.52e-04 5.93e-02 SYNTHESIS SECRETION AND INACTIVATION OF GLP1 6.04e-04 6.41e-02 GLUCAGON SIGNALING IN METABOLIC REGULATION 7.90e-04 8.14e-02 INCRETIN SYNTHESIS SECRETION AND INACTIVATION 9.91e-04 1.17e-01 SYNTHESIS SECRETION AND INACTIVATION OF GLP1 1.04e-03 1.22e-01 G ALPHA Z SIGNALLING EVENTS 1.20e-03 1.38e-01 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 1.29e-03 1.26e-01 REGULATION OF WATER BALANCE BY RENAL AQUAPORINS

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Mouse mutant phenotypes

P-value1 FDR2 Term 2.81e-05 9.84e-02 abnormal tail hair pigmentation 8.01e-05 1.96e-01 abnormal food intake 1.88e-04 3.35e-01 abnormal noradrenaline level 2.05e-04 3.55e-01 decreased respiratory quotient 2.40e-04 3.93e-01 small heart 6.57e-04 7.13e-01 abnormal lymph organ development 8.50e-04 8.22e-01 diluted coat color 8.55e-04 8.24e-01 lymphedema 9.51e-04 8.78e-01 abnormal iris pigmentation 1.18e-03 9.89e-01 abnormal drinking behavior 1.27e-03 1.00e+00 abnormal coat/hair pigmentation 1.29e-03 1.00e+00 maternal imprinting 1.38e-03 1.00e+00 increased circulating glycerol level 1.48e-03 1.00e+00 increased food intake 2.14e-03 1.00e+00 abnormal response/metabolism to endogenous compounds 3.35e-03 1.00e+00 increased circulating corticosterone level 5.02e-03 1.00e+00 increased brown adipose tissue amount 5.65e-03 1.00e+00 increased birth weight 7.48e-03 1.00e+00 abnormal pinna hair pigmentation 7.49e-03 1.00e+00 abnormal uterine spiral artery remodeling

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)