Back to main page

DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod236

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod236 Module size 16 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 20 ABCA2 ATP binding cassette subfamily A member 2 10347 ABCA7 ATP binding cassette subfamily A member 7 10058 ABCB6 ATP binding cassette subfamily B member 6 (Langereis blood group) 11194 ABCB8 ATP binding cassette subfamily B member 8 478 ATP1A1 ATPase Na+/K+ transporting subunit alpha 3 477 ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 478 ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 480 ATP1A4 ATPase Na+/K+ transporting subunit alpha 4 481 ATP1B1 ATPase Na+/K+ transporting subunit beta 1 482 ATP1B2 ATPase Na+/K+ transporting subunit beta 2 483 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 23439 ATP1B4 ATPase Na+/K+ transporting family member beta 4 486 FXYD2 FXYD domain containing ion transport regulator 2 53828 FXYD4 FXYD domain containing ion transport regulator 4 53826 FXYD6 FXYD domain containing ion transport regulator 6 53822 FXYD7 FXYD domain containing ion transport regulator 7

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

Most specific annotations for this module

Coeff.1 P-value.2 Source.3 Term.4 Class.5 3.69e-01 1.76e-27 GO sodium:potassium-exchanging ATPase complex cellular_component 2.11e-01 4.88e-06 Reactome Mitochondrial ABC transporters Transport of small molecules 1.14e-01 2.28e-26 GO sodium:potassium-exchanging ATPase activity molecular_function 6.33e-02 6.39e-26 GO sodium ion export across plasma membrane biological_process 4.60e-02 2.06e-22 GO establishment or maintenance of transmembrane electrochemical gradient biological_process 4.16e-02 3.46e-26 Reactome Ion homeostasis Muscle contraction 1.85e-02 2.41e-09 GO regulation of sodium ion transmembrane transporter activity biological_process 1.31e-02 8.82e-14 GO membrane repolarization biological_process 5.70e-03 7.86e-26 Reactome Ion transport by P-type ATPases Transport of small molecules

¹Regression coefficient

²Fisher’s exact test nominal P-value

³Annotation source (Reactome, GO biological process (BP), molecular function (MF) and cellular component (CC))

⁴GO category or Reactome pathway

⁵High-level branch of annotation tree

Gene membership

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 0e+00 0e+00 monovalent inorganic cation transport 0e+00 0e+00 potassium ion transport 0e+00 0e+00 sodium ion transport 0e+00 0e+00 ATP hydrolysis coupled transmembrane transport 0e+00 0e+00 regulation of heart contraction 0e+00 0e+00 regulation of cardiac conduction 0e+00 0e+00 establishment or maintenance of transmembrane electrochemical gradient 0e+00 0e+00 sodium ion export from cell 0e+00 0e+00 potassium ion transmembrane transport 0e+00 0e+00 regulation of sodium ion transmembrane transport 0e+00 0e+00 regulation of sodium ion transport 0e+00 0e+00 sodium ion export 0e+00 0e+00 potassium ion import 0e+00 0e+00 cellular sodium ion homeostasis 0e+00 0e+00 potassium ion homeostasis 0e+00 0e+00 cellular potassium ion homeostasis 0e+00 0e+00 cation-transporting ATPase complex 0e+00 0e+00 transmembrane transporter complex 0e+00 0e+00 sodium:potassium-exchanging ATPase complex 0e+00 0e+00 ATPase activity

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 0.00e+00 0.00e+00 TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 0.00e+00 0.00e+00 ION CHANNEL TRANSPORT 0.00e+00 0.00e+00 ION TRANSPORT BY P TYPE ATPASES 0.00e+00 0.00e+00 ION CHANNEL TRANSPORT 0.00e+00 0.00e+00 ION TRANSPORT BY P TYPE ATPASES 3.64e-06 5.81e-04 BASIGIN INTERACTIONS 6.55e-05 1.06e-02 ABC FAMILY PROTEINS MEDIATED TRANSPORT 1.08e-04 1.66e-02 BASIGIN INTERACTIONS 1.62e-04 1.96e-02 ABC FAMILY PROTEINS MEDIATED TRANSPORT 2.30e-04 2.69e-02 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 4.72e-04 6.12e-02 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 4.77e-04 6.17e-02 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 2.78e-03 2.48e-01 ABCA TRANSPORTERS IN LIPID HOMEOSTASIS

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Mouse mutant phenotypes

P-value1 FDR2 Term 9.12e-05 2.12e-01 enhanced behavioral response to addictive substance 3.29e-04 4.73e-01 enhanced coordination 3.74e-03 1.00e+00 abnormal sensorimotor gating 3.74e-03 1.00e+00 abnormal habituation 5.31e-03 1.00e+00 abnormal seizure response to inducing agent 5.61e-03 1.00e+00 abnormal non-rapid eye movement sleep pattern 5.83e-03 1.00e+00 decreased cardiac muscle contractility 7.47e-03 1.00e+00 abnormal renal glomerular filtration rate 7.47e-03 1.00e+00 abnormal paradoxical sleep pattern 7.47e-03 1.00e+00 abnormal amygdala morphology 7.47e-03 1.00e+00 abnormal olfactory cortex morphology 7.48e-03 1.00e+00 abnormal respiratory function 9.04e-03 1.00e+00 increased anxiety-related response 9.34e-03 1.00e+00 increased fear-related response 1.12e-02 1.00e+00 abnormal ion homeostasis 1.12e-02 1.00e+00 impaired muscle contractility 1.30e-02 1.00e+00 reduced hyperactivated sperm motility 1.30e-02 1.00e+00 enhanced conditioned place preference behavior 1.30e-02 1.00e+00 abnormal fear/anxiety-related behavior 1.31e-02 1.00e+00 eyelids fail to open

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)