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DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod234

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod234 Module size 17 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 55054 ATG16L1 autophagy related 16 like 1 26190 FBXW2 F-box and WD repeat domain containing 2 54584 GNB1L G protein subunit beta 1 like 10300 KATNB1 katanin regulatory subunit B1 644890 MEIG1 meiosis/spermiogenesis associated 1 5191 PEX7 peroxisomal biogenesis factor 7 25886 POC1A POC1 centriolar protein A 282809 POC1B POC1 centriolar protein B 79582 SPAG16 sperm associated antigen 16 26608 TBL2 transducin beta like 2 57418 WDR18 WD repeat domain 18 22884 WDR37 WD repeat domain 37 348793 WDR53 WD repeat domain 53 84292 WDR83 WD repeat domain 83 349136 WDR86 WD repeat domain 86 151525 WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 26118 WSB1 WD repeat and SOCS box containing 1

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

No specific annotations were found for this module

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 1.16e-04 2.35e-02 ubiquitin-like protein transferase activity 2.08e-04 5.41e-02 endochondral bone morphogenesis 2.28e-04 4.05e-02 spindle pole 4.44e-04 1.02e-01 bone morphogenesis 8.82e-04 1.38e-01 peroxisome targeting sequence binding 9.79e-04 1.94e-01 organelle assembly 1.26e-03 1.78e-01 cilium 1.95e-03 3.34e-01 growth plate cartilage chondrocyte differentiation 1.95e-03 3.34e-01 chondrocyte development 1.95e-03 3.34e-01 growth plate cartilage chondrocyte development 1.95e-03 3.34e-01 chondrocyte development involved in endochondral bone morphogenesis 1.95e-03 3.34e-01 negative stranded viral RNA replication 2.01e-03 2.63e-01 spindle 2.23e-03 3.72e-01 cilium assembly 2.23e-03 3.72e-01 cilium organization 2.37e-03 3.02e-01 axonemal central apparatus 2.37e-03 3.26e-01 ubiquitin-protein transferase activity 2.45e-03 4.01e-01 regulation of microtubule cytoskeleton organization 2.87e-03 4.56e-01 positive regulation of cytoskeleton organization 3.28e-03 5.07e-01 regulation of microtubule-based process

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 1.31e-02 9.85e-01 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 2.20e-02 1.00e+00 PROTEIN FOLDING 2.38e-02 1.00e+00 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS 4.52e-02 1.00e+00 PROTEIN FOLDING

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Mouse mutant phenotypes

P-value1 FDR2 Term 1.34e-05 5.71e-02 abnormal sperm axoneme morphology 3.17e-04 4.66e-01 arrest of spermatogenesis 5.43e-04 6.39e-01 disproportionate dwarf 9.70e-04 8.90e-01 asthenozoospermia 2.23e-03 1.00e+00 oligozoospermia 2.93e-03 1.00e+00 abnormal sperm flagellum morphology 3.74e-03 1.00e+00 short lumbar vertebrae 5.61e-03 1.00e+00 decreased renal tubule apoptosis 7.47e-03 1.00e+00 lipidosis 7.47e-03 1.00e+00 increased macrophage cytokine production 7.47e-03 1.00e+00 increased interleukin-18 secretion 9.33e-03 1.00e+00 enlarged sperm head 9.34e-03 1.00e+00 dystonia 9.46e-03 1.00e+00 teratozoospermia 1.12e-02 1.00e+00 abnormal lens capsule morphology 1.12e-02 1.00e+00 decreased susceptibility to kidney reperfusion injury 1.30e-02 1.00e+00 abnormal Paneth cell morphology 1.30e-02 1.00e+00 abnormal manchette morphology 1.31e-02 1.00e+00 small gonad 1.45e-02 1.00e+00 abnormal seminiferous tubule morphology

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)