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DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod225

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod225 Module size 13 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 157 ADRBK2 G protein-coupled receptor kinase 3 409 ARRB2 arrestin beta 2 81563 C1orf21 chromosome 1 open reading frame 21 55332 DRAM1 DNA damage regulated autophagy modulator 1 2774 GNAL G protein subunit alpha L 2792 GNGT1 G protein subunit gamma transducin 1 29991 OBP2A odorant binding protein 2A 128367 OR10X1 olfactory receptor family 10 subfamily X member 1 (gene/pseudogene) 128368 OR10Z1 olfactory receptor family 10 subfamily Z member 1 440153 OR11H12 olfactory receptor family 11 subfamily H member 12 8386 OR1D5 olfactory receptor family 1 subfamily D member 5 346528 OR2A1 olfactory receptor family 2 subfamily A member 1 729759 OR4F29 olfactory receptor family 4 subfamily F member 29

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

No specific annotations were found for this module

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 2.49e-05 8.71e-03 sensory perception of smell 2.86e-05 9.85e-03 sensory perception of chemical stimulus 3.94e-05 1.31e-02 detection of stimulus 3.49e-04 8.34e-02 detection of stimulus involved in sensory perception 4.28e-04 9.86e-02 dopamine receptor signaling pathway 7.07e-04 1.14e-01 olfactory receptor activity 9.89e-04 1.96e-01 detection of abiotic stimulus 1.37e-03 1.91e-01 heterotrimeric G-protein complex 1.50e-03 2.19e-01 odorant binding 1.95e-03 3.34e-01 cardiac muscle cell apoptotic process 1.95e-03 3.34e-01 muscle cell apoptotic process 1.97e-03 2.78e-01 type 2A serotonin receptor binding 2.00e-03 3.41e-01 desensitization of G-protein coupled receptor protein signaling pathway by arrestin 2.12e-03 2.96e-01 G-protein coupled receptor activity 2.93e-03 4.64e-01 detection of chemical stimulus involved in sensory perception of smell 3.06e-03 4.80e-01 regulation of G-protein coupled receptor protein signaling pathway 3.08e-03 4.83e-01 detection of chemical stimulus involved in sensory perception 3.37e-03 5.18e-01 detection of chemical stimulus 3.44e-03 4.12e-01 extrinsic component of cytoplasmic side of plasma membrane 3.50e-03 4.54e-01 GTPase activity

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 2.17e-06 4.61e-04 OLFACTORY SIGNALING PATHWAY 9.79e-04 9.90e-02 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 1.47e-03 1.42e-01 GABA B RECEPTOR ACTIVATION 2.72e-03 2.43e-01 GABA RECEPTOR ACTIVATION 3.39e-03 3.32e-01 GABA B RECEPTOR ACTIVATION 3.55e-03 3.44e-01 GABA RECEPTOR ACTIVATION 4.35e-03 3.65e-01 OPIOID SIGNALLING 4.56e-03 4.23e-01 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 1.53e-02 1.00e+00 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 1.74e-02 1.00e+00 PLATELET ACTIVATION SIGNALING AND AGGREGATION 1.79e-02 1.00e+00 ADENYLATE CYCLASE ACTIVATING PATHWAY 2.09e-02 1.00e+00 OPIOID SIGNALLING 2.15e-02 1.00e+00 NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 2.32e-02 1.00e+00 ADENYLATE CYCLASE INHIBITORY PATHWAY 2.37e-02 1.00e+00 TRANSMISSION ACROSS CHEMICAL SYNAPSES 2.47e-02 1.00e+00 TRANSMISSION ACROSS CHEMICAL SYNAPSES 2.83e-02 1.00e+00 NEURONAL SYSTEM 3.08e-02 1.00e+00 NEURONAL SYSTEM 3.20e-02 1.00e+00 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 3.21e-02 1.00e+00 ADENYLATE CYCLASE ACTIVATING PATHWAY

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Mouse mutant phenotypes

P-value1 FDR2 Term 1.10e-03 9.51e-01 taste/olfaction phenotype 3.74e-03 1.00e+00 increased chemically-elicited antinociception 3.74e-03 1.00e+00 increased interleukin-12b secretion 3.75e-03 1.00e+00 retinal outer nuclear layer degeneration 3.76e-03 1.00e+00 abnormal lymphocyte physiology 5.60e-03 1.00e+00 absent maternal crouching 5.60e-03 1.00e+00 abnormal response to novel odor 5.60e-03 1.00e+00 abnormal circulating tumor necrosis factor level 7.46e-03 1.00e+00 photosensitivity 7.47e-03 1.00e+00 abnormal pup retrieval 9.36e-03 1.00e+00 increased acute inflammation 9.39e-03 1.00e+00 increased circulating interleukin-6 level 1.12e-02 1.00e+00 abnormal olfaction 1.12e-02 1.00e+00 retinal rod cell degeneration 1.12e-02 1.00e+00 abnormal body temperature homeostasis 1.31e-02 1.00e+00 abnormal maternal nurturing 1.49e-02 1.00e+00 short photoreceptor outer segment 1.50e-02 1.00e+00 abnormal olfactory system physiology 1.50e-02 1.00e+00 retinal photoreceptor degeneration 2.06e-02 1.00e+00 abnormal suckling behavior

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)