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DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod224

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod224 Module size 40 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 26476 OR10J1 olfactory receptor family 10 subfamily J member 1 390201 OR10V1 olfactory receptor family 10 subfamily V member 1 391189 OR11L1 olfactory receptor family 11 subfamily L member 1 138802 OR13C8 olfactory receptor family 13 subfamily C member 8 219958 OR1S2 olfactory receptor family 1 subfamily S member 2 135941 OR2A14 olfactory receptor family 2 subfamily A member 14 120775 OR2D3 olfactory receptor family 2 subfamily D member 3 26211 OR2F1 olfactory receptor family 2 subfamily F member 1 (gene/pseudogene) 81470 OR2G2 olfactory receptor family 2 subfamily G member 2 56656 OR2S2 olfactory receptor family 2 subfamily S member 2 (gene/pseudogene) 401992 OR2T2 olfactory receptor family 2 subfamily T member 2 401993 OR2T5 olfactory receptor family 2 subfamily T member 5 4995 OR3A2 olfactory receptor family 3 subfamily A member 2 81328 OR4A15 olfactory receptor family 4 subfamily A member 15 403253 OR4A47 olfactory receptor family 4 subfamily A member 47 26686 OR4E2 olfactory receptor family 4 subfamily E member 2 390649 OR4F15 olfactory receptor family 4 subfamily F member 15 401666 OR51A4 olfactory receptor family 51 subfamily A member 4 282763 OR51B5 olfactory receptor family 51 subfamily B member 5 390058 OR51B6 olfactory receptor family 51 subfamily B member 6 143503 OR51E1 olfactory receptor family 51 subfamily E member 1 390064 OR51I2 olfactory receptor family 51 subfamily I member 2 390059 OR51M1 olfactory receptor family 51 subfamily M member 1 401665 OR51T1 olfactory receptor family 51 subfamily T member 1 23538 OR52A1 olfactory receptor family 52 subfamily A member 1 255725 OR52B2 olfactory receptor family 52 subfamily B member 2 120796 OR56A1 olfactory receptor family 56 subfamily A member 1 390083 OR56A3 olfactory receptor family 56 subfamily A member 3 219981 OR5A2 olfactory receptor family 5 subfamily A member 2 390445 OR5AU1 olfactory receptor family 5 subfamily AU member 1 390144 OR5D16 olfactory receptor family 5 subfamily D member 16 10798 OR5I1 olfactory receptor family 5 subfamily I member 1 390167 OR5M10 olfactory receptor family 5 subfamily M member 10 219487 OR5M11 olfactory receptor family 5 subfamily M member 11 390261 OR6M1 olfactory receptor family 6 subfamily M member 1 26333 OR7A17 olfactory receptor family 7 subfamily A member 17 125958 OR7D4 olfactory receptor family 7 subfamily D member 4 283162 OR8B4 olfactory receptor family 8 subfamily B member 4 (gene/pseudogene) 120586 OR8I2 olfactory receptor family 8 subfamily I member 2 441639 OR9K2 olfactory receptor family 9 subfamily K member 2

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

Most specific annotations for this module

Coeff.1 P-value.2 Source.3 Term.4 Class.5 5.67e-02 5.80e-66 Reactome Olfactory Signaling Pathway Signal Transduction 2.40e-02 1.82e-25 GO sensory perception of smell biological_process 1.28e-03 7.92e-61 Reactome G alpha (s) signalling events Signal Transduction

¹Regression coefficient

²Fisher’s exact test nominal P-value

³Annotation source (Reactome, GO biological process (BP), molecular function (MF) and cellular component (CC))

⁴GO category or Reactome pathway

⁵High-level branch of annotation tree

Gene membership

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 0.00e+00 0.00e+00 sensory perception of chemical stimulus 0.00e+00 0.00e+00 detection of stimulus involved in sensory perception 0.00e+00 0.00e+00 detection of chemical stimulus involved in sensory perception 0.00e+00 0.00e+00 detection of chemical stimulus 0.00e+00 0.00e+00 sensory perception of smell 0.00e+00 0.00e+00 detection of stimulus 0.00e+00 0.00e+00 detection of chemical stimulus involved in sensory perception of smell 0.00e+00 0.00e+00 G-protein coupled receptor activity 0.00e+00 0.00e+00 olfactory receptor activity 0.00e+00 0.00e+00 odorant binding 3.67e-03 4.73e-01 dopamine neurotransmitter receptor activity 3.67e-03 4.73e-01 dopamine binding 3.67e-03 4.73e-01 dopamine neurotransmitter receptor activity, coupled via Gi/Go 5.84e-03 7.72e-01 negative regulation of voltage-gated calcium channel activity 5.84e-03 7.72e-01 negative regulation of synaptic transmission, glutamatergic 7.78e-03 9.47e-01 adenylate cyclase-inhibiting dopamine receptor signaling pathway 7.78e-03 9.47e-01 negative regulation of cytosolic calcium ion concentration 7.79e-03 9.47e-01 negative regulation of adenylate cyclase activity 7.79e-03 9.47e-01 negative regulation of lyase activity 9.72e-03 1.00e+00 phospholipase C-activating dopamine receptor signaling pathway

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 0e+00 0e+00 OLFACTORY SIGNALING PATHWAY

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)