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DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod222

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod222 Module size 60 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 26496 OR10A3 olfactory receptor family 10 subfamily A member 3 283297 OR10A4 olfactory receptor family 10 subfamily A member 4 144124 OR10A5 olfactory receptor family 10 subfamily A member 5 282770 OR10AG1 olfactory receptor family 10 subfamily AG member 1 26533 OR10G3 olfactory receptor family 10 subfamily G member 3 284433 OR10H5 olfactory receptor family 10 subfamily H member 5 122748 OR11H6 olfactory receptor family 11 subfamily H member 6 138804 OR13C4 olfactory receptor family 13 subfamily C member 4 286365 OR13D1 olfactory receptor family 13 subfamily D member 1 441933 OR13G1 olfactory receptor family 13 subfamily G member 1 347468 OR13H1 olfactory receptor family 13 subfamily H member 1 284532 OR14A16 olfactory receptor family 14 subfamily A member 16 8383 OR1A1 olfactory receptor family 1 subfamily A member 1 26188 OR1C1 olfactory receptor family 1 subfamily C member 1 26735 OR1L3 olfactory receptor family 1 subfamily L member 3 219959 OR1S1 olfactory receptor family 1 subfamily S member 1 (gene/pseudogene) 346525 OR2A12 olfactory receptor family 2 subfamily A member 12 81697 OR2B2 olfactory receptor family 2 subfamily B member 2 81472 OR2C3 olfactory receptor family 2 subfamily C member 3 26246 OR2L2 olfactory receptor family 2 subfamily L member 2 127062 OR2M3 olfactory receptor family 2 subfamily M member 3 403239 OR2T27 olfactory receptor family 2 subfamily T member 27 127074 OR2T4 olfactory receptor family 2 subfamily T member 4 254879 OR2T6 olfactory receptor family 2 subfamily T member 6 81327 OR4A16 olfactory receptor family 4 subfamily A member 16 219429 OR4C11 olfactory receptor family 4 subfamily C member 11 81309 OR4C15 olfactory receptor family 4 subfamily C member 15 219428 OR4C16 olfactory receptor family 4 subfamily C member 16 (gene/pseudogene) 119749 OR4C46 olfactory receptor family 4 subfamily C member 46 81099 OR4F17 olfactory receptor family 4 subfamily F member 17 26682 OR4F4 olfactory receptor family 4 subfamily F member 4 79501 OR4F5 olfactory receptor family 4 subfamily F member 5 122742 OR4L1 olfactory receptor family 4 subfamily L member 1 441670 OR4M1 olfactory receptor family 4 subfamily M member 1 390429 OR4N2 olfactory receptor family 4 subfamily N member 2 256148 OR4S1 olfactory receptor family 4 subfamily S member 1 119764 OR4X2 olfactory receptor family 4 subfamily X member 2 (gene/pseudogene) 81285 OR51E2 olfactory receptor family 51 subfamily E member 2 119772 OR52M1 olfactory receptor family 52 subfamily M member 1 390077 OR52N2 olfactory receptor family 52 subfamily N member 2 196335 OR56B4 olfactory receptor family 56 subfamily B member 4 441608 OR5B3 olfactory receptor family 5 subfamily B member 3 403273 OR5H14 olfactory receptor family 5 subfamily H member 14 79310 OR5H2 olfactory receptor family 5 subfamily H member 2 26339 OR5K1 olfactory receptor family 5 subfamily K member 1 219437 OR5L1 olfactory receptor family 5 subfamily L member 1 (gene/pseudogene) 390168 OR5M1 olfactory receptor family 5 subfamily M member 1 219482 OR5M3 olfactory receptor family 5 subfamily M member 3 389090 OR6B2 olfactory receptor family 6 subfamily B member 2 341416 OR6C2 olfactory receptor family 6 subfamily C member 2 254786 OR6C3 olfactory receptor family 6 subfamily C member 3 390327 OR6C70 olfactory receptor family 6 subfamily C member 70 128366 OR6P1 olfactory receptor family 6 subfamily P member 1 26659 OR7A5 olfactory receptor family 7 subfamily A member 5 390882 OR7G2 olfactory receptor family 7 subfamily G member 2 219858 OR8B12 olfactory receptor family 8 subfamily B member 12 390271 OR8B3 olfactory receptor family 8 subfamily B member 3 390151 OR8H2 olfactory receptor family 8 subfamily H member 2 341568 OR8S1 olfactory receptor family 8 subfamily S member 1 219957 OR9Q2 olfactory receptor family 9 subfamily Q member 2

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

Most specific annotations for this module

Coeff.1 P-value.2 Source.3 Term.4 Class.5 1.03e-01 3.08e-99 Reactome Olfactory Signaling Pathway Signal Transduction 6.93e-03 2.33e-91 Reactome G alpha (s) signalling events Signal Transduction

¹Regression coefficient

²Fisher’s exact test nominal P-value

³Annotation source (Reactome, GO biological process (BP), molecular function (MF) and cellular component (CC))

⁴GO category or Reactome pathway

⁵High-level branch of annotation tree

Gene membership

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 0.00e+00 0.00e+00 sensory perception of chemical stimulus 0.00e+00 0.00e+00 detection of stimulus involved in sensory perception 0.00e+00 0.00e+00 detection of chemical stimulus involved in sensory perception 0.00e+00 0.00e+00 detection of chemical stimulus 0.00e+00 0.00e+00 sensory perception of smell 0.00e+00 0.00e+00 detection of stimulus 0.00e+00 0.00e+00 detection of chemical stimulus involved in sensory perception of smell 0.00e+00 0.00e+00 G-protein coupled receptor activity 0.00e+00 0.00e+00 odorant binding 0.00e+00 0.00e+00 olfactory receptor activity 1.95e-03 3.34e-01 regulation of renin secretion into blood stream 3.16e-03 4.92e-01 positive regulation of protein transport 7.80e-03 9.47e-01 positive regulation of blood pressure 1.36e-02 1.00e+00 cellular response to fatty acid 1.95e-02 1.00e+00 response to fatty acid 1.96e-02 1.00e+00 positive regulation of protein secretion 2.13e-02 1.00e+00 G-protein coupled serotonin receptor activity 2.14e-02 1.00e+00 regulation of systemic arterial blood pressure 2.16e-02 1.00e+00 positive regulation of peptide secretion 2.38e-02 1.00e+00 neurotransmitter receptor activity

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 0e+00 0e+00 OLFACTORY SIGNALING PATHWAY

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Mouse mutant phenotypes

P-value1 FDR2 Term 7.18e-06 3.69e-02 abnormal olfactory neuron innervation pattern 1.63e-05 6.60e-02 abnormal olfactory bulb development 4.29e-04 5.54e-01 taste/olfaction phenotype 1.88e-03 1.00e+00 abnormal olfactory bulb morphology

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)