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DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod206

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod206 Module size 35 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 7593 MZF1 myeloid zinc finger 1 84547 PGBD1 piggyBac transposable element derived 1 51282 SCAND1 SCAN domain containing 1 55734 ZFP64 ZFP64 zinc finger protein 7586 ZKSCAN1 zinc finger with KRAB and SCAN domains 1 387032 ZKSCAN4 zinc finger with KRAB and SCAN domains 4 7718 ZNF165 zinc finger protein 165 55888 ZNF167 zinc finger with KRAB and SCAN domains 7 7727 ZNF174 zinc finger protein 174 7745 ZNF192 zinc finger with KRAB and SCAN domains 8 7746 ZNF193 zinc finger and SCAN domain containing 9 10168 ZNF20 zinc finger protein 197 7753 ZNF202 zinc finger protein 202 7775 ZNF232 zinc finger protein 232 7572 ZNF24 zinc finger protein 24 10127 ZNF263 zinc finger protein 263 252884 ZNF396 zinc finger protein 396 84307 ZNF397 zinc finger protein 397 57862 ZNF410 zinc finger protein 410 54925 ZNF434 zinc finger and SCAN domain containing 32 55663 ZNF446 zinc finger protein 446 90333 ZNF468 zinc finger protein 468 158399 ZNF483 zinc finger protein 483 84838 ZNF496 zinc finger protein 496 9831 ZNF623 zinc finger protein 623 63934 ZNF667 zinc finger protein 667 7621 ZNF70 zinc finger protein 70 100129842 ZNF737 zinc finger protein 737 155061 ZNF746 zinc finger protein 746 9753 ZSCAN12 zinc finger and SCAN domain containing 12 80345 ZSCAN16 zinc finger and SCAN domain containing 16 7579 ZSCAN20 zinc finger and SCAN domain containing 20 7589 ZSCAN21 zinc finger and SCAN domain containing 21 342945 ZSCAN22 zinc finger and SCAN domain containing 22 55663 ZSCAN30 zinc finger protein 446

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

No specific annotations were found for this module

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 5.07e-08 2.03e-05 RNA polymerase II transcription factor activity, sequence-specific DNA binding 2.87e-05 9.88e-03 negative regulation of transcription from RNA polymerase II promoter 1.88e-04 4.98e-02 transcription from RNA polymerase II promoter 1.96e-03 3.36e-01 myelination 1.96e-03 3.36e-01 positive regulation of neuron death 6.23e-03 7.35e-01 transcription regulatory region DNA binding 6.27e-03 7.39e-01 regulatory region DNA binding 7.43e-03 8.47e-01 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding 7.82e-03 9.48e-01 axon ensheathment 9.88e-03 1.00e+00 regulation of neuron death 1.12e-02 1.00e+00 RNA polymerase II core promoter proximal region sequence-specific DNA binding 1.19e-02 1.00e+00 core promoter proximal region sequence-specific DNA binding 1.19e-02 1.00e+00 core promoter proximal region DNA binding 1.21e-02 1.00e+00 positive regulation of cell death 1.35e-02 1.00e+00 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding 1.41e-02 1.00e+00 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 2.26e-02 1.00e+00 RNA polymerase II regulatory region sequence-specific DNA binding 2.26e-02 1.00e+00 RNA polymerase II regulatory region DNA binding 2.28e-02 1.00e+00 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding 2.73e-02 1.00e+00 transcription regulatory region sequence-specific DNA binding

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 0e+00 0e+00 GENERIC TRANSCRIPTION PATHWAY

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Mouse mutant phenotypes

P-value1 FDR2 Term 1.87e-03 1e+00 abnormal bone marrow development 1.87e-03 1e+00 abnormal spinal cord white matter morphology 1.87e-03 1e+00 decreased spinal cord size 1.87e-03 1e+00 decreased oligodendrocyte number 1.87e-03 1e+00 abnormal extraembryonic tissue physiology 3.74e-03 1e+00 decreased myelin sheath thickness 3.75e-03 1e+00 tonic seizures 9.36e-03 1e+00 abnormal myelopoiesis 1.31e-02 1e+00 abnormal myelin sheath morphology 1.67e-02 1e+00 inner cell mass degeneration 1.68e-02 1e+00 absent inner cell mass proliferation 1.69e-02 1e+00 extramedullary hematopoiesis 2.06e-02 1e+00 decreased brain size 2.19e-02 1e+00 abnormal bone mineralization 2.33e-02 1e+00 abnormal myelination 3.20e-02 1e+00 tremors 3.87e-02 1e+00 increased hepatocellular carcinoma incidence 3.97e-02 1e+00 increased or absent threshold for auditory brainstem response

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)