Back to main page

DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod203

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod203 Module size 27 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 3750 KCND1 potassium voltage-gated channel subfamily D member 1 23704 KCNE4 potassium voltage-gated channel subfamily E regulatory subunit 4 3775 KCNK1 potassium two pore domain channel subfamily K member 1 54207 KCNK10 potassium two pore domain channel subfamily K member 10 83795 KCNK16 potassium two pore domain channel subfamily K member 16 89822 KCNK17 potassium two pore domain channel subfamily K member 17 338567 KCNK18 potassium two pore domain channel subfamily K member 18 3776 KCNK2 potassium two pore domain channel subfamily K member 2 50801 KCNK4 potassium two pore domain channel subfamily K member 4 8645 KCNK5 potassium two pore domain channel subfamily K member 5 9424 KCNK6 potassium two pore domain channel subfamily K member 6 10089 KCNK7 potassium two pore domain channel subfamily K member 7 3781 KCNN2 potassium calcium-activated channel subfamily N member 2 3782 KCNN3 potassium calcium-activated channel subfamily N member 3 3783 KCNN4 potassium calcium-activated channel subfamily N member 4 283518 KCNRG potassium channel regulator 259232 NALCN sodium leak channel, non-selective 1728 NQO1 NAD(P)H quinone dehydrogenase 1 4835 NQO2 N-ribosyldihydronicotinamide:quinone reductase 2 6549 SLC9A2 solute carrier family 9 member A2 389015 SLC9A4 solute carrier family 9 member A4 6553 SLC9A5 solute carrier family 9 member A5 150159 SLC9B1 solute carrier family 9 member B1 100128190 SLC9B1P1 solute carrier family 9 member B1 pseudogene 1 133308 SLC9B2 solute carrier family 9 member B2 57578 UNC79 unc-79 homolog, NALCN channel complex subunit 285175 UNC80 unc-80 homolog, NALCN channel complex subunit

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

Most specific annotations for this module

Coeff.1 P-value.2 Source.3 Term.4 Class.5 2.49e-01 3.08e-09 Reactome TWIK related potassium channel (TREK) Neuronal System 2.49e-01 3.08e-09 Reactome Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Neuronal System 2.28e-01 1.92e-24 Reactome Tandem pore domain potassium channels Neuronal System 2.17e-01 6.74e-12 GO sodium:proton antiporter activity molecular_function 1.88e-01 2.20e-06 Reactome TWIK-related alkaline pH activated K+ channel (TALK) Neuronal System 1.57e-01 6.89e-26 GO potassium ion leak channel activity molecular_function 1.44e-01 2.57e-07 Reactome Ca2+ activated K+ channels Neuronal System 4.93e-02 1.51e-03 Reactome TWIK-related spinal cord K+ channel (TRESK) Neuronal System 3.78e-02 7.93e-25 Reactome Phase 4 - resting membrane potential Muscle contraction 4.42e-04 1.11e-21 GO potassium channel activity molecular_function

¹Regression coefficient

²Fisher’s exact test nominal P-value

³Annotation source (Reactome, GO biological process (BP), molecular function (MF) and cellular component (CC))

⁴GO category or Reactome pathway

⁵High-level branch of annotation tree

Gene membership

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 0.00e+00 0.00e+00 potassium ion transmembrane transport 0.00e+00 0.00e+00 monovalent inorganic cation transport 0.00e+00 0.00e+00 regulation of ion transport 0.00e+00 0.00e+00 potassium ion transport 0.00e+00 0.00e+00 cation transmembrane transport 0.00e+00 0.00e+00 regulation of ion transmembrane transport 0.00e+00 0.00e+00 metal ion transport 0.00e+00 0.00e+00 inorganic cation transmembrane transporter activity 0.00e+00 0.00e+00 monovalent inorganic cation transmembrane transporter activity 0.00e+00 0.00e+00 cation channel activity 0.00e+00 0.00e+00 cation transmembrane transporter activity 0.00e+00 0.00e+00 metal ion transmembrane transporter activity 0.00e+00 0.00e+00 potassium ion transmembrane transporter activity 0.00e+00 0.00e+00 potassium channel activity 4.61e-11 2.89e-08 voltage-gated ion channel activity 7.57e-11 4.67e-08 ion channel activity 1.25e-10 7.55e-08 channel activity 1.26e-10 7.61e-08 passive transmembrane transporter activity 6.12e-09 2.87e-06 solute:proton antiporter activity 1.50e-08 5.80e-06 potassium channel complex

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 0.00e+00 0.00e+00 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.00e+00 0.00e+00 POTASSIUM CHANNELS 0.00e+00 0.00e+00 NEURONAL SYSTEM 0.00e+00 0.00e+00 TANDEM PORE DOMAIN POTASSIUM CHANNELS 0.00e+00 0.00e+00 POTASSIUM CHANNELS 0.00e+00 0.00e+00 NEURONAL SYSTEM 3.26e-03 2.86e-01 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 8.73e-03 7.18e-01 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 2.23e-02 1.00e+00 REGULATION OF ORNITHINE DECARBOXYLASE ODC 3.47e-02 1.00e+00 SLC MEDIATED TRANSMEMBRANE TRANSPORT 4.03e-02 1.00e+00 REGULATION OF ORNITHINE DECARBOXYLASE ODC 4.32e-02 1.00e+00 SLC MEDIATED TRANSMEMBRANE TRANSPORT

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Mouse mutant phenotypes

P-value1 FDR2 Term 1.05e-04 2.33e-01 hypochlorhydria 2.20e-04 3.69e-01 increased skin tumor incidence 3.91e-04 5.24e-01 apnea 4.46e-04 5.67e-01 stomach inflammation 4.88e-04 5.99e-01 abnormal stomach glandular epithelium morphology 7.51e-04 7.64e-01 increased systemic arterial diastolic blood pressure 7.52e-04 7.64e-01 increased mean systemic arterial blood pressure 1.54e-03 1.00e+00 abnormal gastric parietal cell morphology 1.61e-03 1.00e+00 increased granulocyte number 1.87e-03 1.00e+00 abnormal renal phosphate reabsorbtion 2.24e-03 1.00e+00 abnormal action potential 3.52e-03 1.00e+00 increased systemic arterial systolic blood pressure 3.74e-03 1.00e+00 enhanced behavioral response to alcohol 3.74e-03 1.00e+00 abnormal red blood cell deformability 5.61e-03 1.00e+00 decreased urine flow rate 5.61e-03 1.00e+00 altered response to CNS ischemic injury 7.47e-03 1.00e+00 abnormal mucous neck cell morphology 9.33e-03 1.00e+00 increased hemoglobin concentration distribution width 9.33e-03 1.00e+00 abnormal pulmonary respiratory rate 9.34e-03 1.00e+00 decreased abdominal adipose tissue amount

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)