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DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod19

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod19 Module size 54 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 219873 OR10S1 olfactory receptor family 10 subfamily S member 1 390439 OR11G2 olfactory receptor family 11 subfamily G member 2 81061 OR11H1 olfactory receptor family 11 subfamily H member 1 401994 OR14I1 olfactory receptor family 14 subfamily I member 1 4992 OR1F1 olfactory receptor family 1 subfamily F member 1 26737 OR1L1 olfactory receptor family 1 subfamily L member 1 81392 OR2AE1 olfactory receptor family 2 subfamily AE member 1 338755 OR2AG2 olfactory receptor family 2 subfamily AG member 2 26248 OR2K2 olfactory receptor family 2 subfamily K member 2 391190 OR2L8 olfactory receptor family 2 subfamily L member 8 (gene/pseudogene) 26245 OR2M4 olfactory receptor family 2 subfamily M member 4 127059 OR2M5 olfactory receptor family 2 subfamily M member 5 127064 OR2T12 olfactory receptor family 2 subfamily T member 12 343173 OR2T3 olfactory receptor family 2 subfamily T member 3 26693 OR2V1 olfactory receptor family 2 subfamily V member 1 134083 OR2Y1 olfactory receptor family 2 subfamily Y member 1 8392 OR3A3 olfactory receptor family 3 subfamily A member 3 283093 OR4C12 olfactory receptor family 4 subfamily C member 12 256144 OR4C3 olfactory receptor family 4 subfamily C member 3 79346 OR4C5 olfactory receptor family 4 subfamily C member 5 (gene/pseudogene) 26689 OR4D1 olfactory receptor family 4 subfamily D member 1 390197 OR4D10 olfactory receptor family 4 subfamily D member 10 122740 OR4K14 olfactory receptor family 4 subfamily K member 14 441669 OR4Q3 olfactory receptor family 4 subfamily Q member 3 219431 OR4S2 olfactory receptor family 4 subfamily S member 2 119687 OR51A7 olfactory receptor family 51 subfamily A member 7 79339 OR51B4 olfactory receptor family 51 subfamily B member 4 401663 OR51H1P olfactory receptor family 51 subfamily H member 1 79470 OR51J1 olfactory receptor family 51 subfamily J member 1 (gene/pseudogene) 119692 OR51S1 olfactory receptor family 51 subfamily S member 1 283111 OR51V1 olfactory receptor family 51 subfamily V member 1 340980 OR52B6 olfactory receptor family 52 subfamily B member 6 390078 OR52E6 olfactory receptor family 52 subfamily E member 6 390036 OR52K1 olfactory receptor family 52 subfamily K member 1 338751 OR52L1 olfactory receptor family 52 subfamily L member 1 81050 OR5AC2 olfactory receptor family 5 subfamily AC member 2 219493 OR5AR1 olfactory receptor family 5 subfamily AR member 1 (gene/pseudogene) 219965 OR5B17 olfactory receptor family 5 subfamily B member 17 338674 OR5F1 olfactory receptor family 5 subfamily F member 1 79295 OR5H6 olfactory receptor family 5 subfamily H member 6 (gene/pseudogene) 26338 OR5L2 olfactory receptor family 5 subfamily L member 2 390148 OR5W2 olfactory receptor family 5 subfamily W member 2 254783 OR6C74 olfactory receptor family 6 subfamily C member 74 390326 OR6C76 olfactory receptor family 6 subfamily C member 76 81442 OR6N2 olfactory receptor family 6 subfamily N member 2 341799 OR6S1 olfactory receptor family 6 subfamily S member 1 219874 OR6T1 olfactory receptor family 6 subfamily T member 1 390260 OR6X1 olfactory receptor family 6 subfamily X member 1 390892 OR7A10 olfactory receptor family 7 subfamily A member 10 26664 OR7C1 olfactory receptor family 7 subfamily C member 1 26493 OR8B8 olfactory receptor family 8 subfamily B member 8 283160 OR8D2 olfactory receptor family 8 subfamily D member 2 (gene/pseudogene) 219417 OR8U1 olfactory receptor family 8 subfamily U member 1 219956 OR9Q1 olfactory receptor family 9 subfamily Q member 1

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

Most specific annotations for this module

Coeff.1 P-value.2 Source.3 Term.4 Class.5 8.84e-02 1.54e-87 Reactome Olfactory Signaling Pathway Signal Transduction 5.46e-03 1.23e-80 Reactome G alpha (s) signalling events Signal Transduction

¹Regression coefficient

²Fisher’s exact test nominal P-value

³Annotation source (Reactome, GO biological process (BP), molecular function (MF) and cellular component (CC))

⁴GO category or Reactome pathway

⁵High-level branch of annotation tree

Gene membership

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 0.00e+00 0e+00 sensory perception of chemical stimulus 0.00e+00 0e+00 detection of stimulus involved in sensory perception 0.00e+00 0e+00 detection of chemical stimulus involved in sensory perception 0.00e+00 0e+00 detection of chemical stimulus 0.00e+00 0e+00 sensory perception of smell 0.00e+00 0e+00 detection of stimulus 0.00e+00 0e+00 detection of chemical stimulus involved in sensory perception of smell 0.00e+00 0e+00 G-protein coupled receptor activity 0.00e+00 0e+00 olfactory receptor activity 0.00e+00 0e+00 odorant binding 1.98e-02 1e+00 G-protein coupled serotonin receptor activity 2.24e-02 1e+00 neurotransmitter receptor activity

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 0e+00 0e+00 OLFACTORY SIGNALING PATHWAY

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)