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DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod158

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod158 Module size 14 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 257177 C1orf192 cilia and flagella associated protein 126 79598 CEP97 centrosomal protein 97 1770 DNAL1 dynein axonemal heavy chain 9 254050 LRRC43 leucine rich repeat containing 43 90506 LRRC46 leucine rich repeat containing 46 83450 LRRC48 dynein regulatory complex subunit 3 54839 LRRC49 leucine rich repeat containing 49 115399 LRRC56 leucine rich repeat containing 56 23639 LRRC6 leucine rich repeat containing 6 65999 LRRC61 leucine rich repeat containing 61 341883 LRRC9 leucine rich repeat containing 9 85444 LRRCC1 leucine rich repeat and coiled-coil centrosomal protein 1 84125 LRRIQ1 leucine rich repeats and IQ motif containing 1 127255 LRRIQ3 leucine rich repeats and IQ motif containing 3

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

Most specific annotations for this module

Coeff.1 P-value.2 Source.3 Term.4 Class.5 1.04e-01 5.60e-15 GO outer dynein arm assembly biological_process 4.86e-02 1.26e-11 GO dynein heavy chain binding molecular_function

¹Regression coefficient

²Fisher’s exact test nominal P-value

³Annotation source (Reactome, GO biological process (BP), molecular function (MF) and cellular component (CC))

⁴GO category or Reactome pathway

⁵High-level branch of annotation tree

Gene membership

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 1.95e-03 3.34e-01 epithelial cilium movement involved in determination of left/right asymmetry 1.95e-03 3.34e-01 regulation of mitotic spindle assembly 3.03e-03 4.76e-01 cilium assembly 3.15e-03 4.91e-01 cilium organization 3.45e-03 5.28e-01 cell projection assembly 3.89e-03 5.71e-01 outer dynein arm assembly 3.89e-03 5.71e-01 inner dynein arm assembly 3.89e-03 5.71e-01 regulation of spindle assembly 4.71e-03 5.30e-01 centrosome 5.84e-03 7.72e-01 motile cilium assembly 5.84e-03 7.72e-01 axonemal dynein complex assembly 5.84e-03 7.72e-01 regulation of mitotic spindle organization 7.15e-03 8.21e-01 NAD+ ADP-ribosyltransferase activity 7.77e-03 9.47e-01 epithelial cilium movement 7.77e-03 9.47e-01 negative regulation of cilium assembly 9.30e-03 1.00e+00 transferase activity, transferring pentosyl groups 9.48e-03 8.94e-01 microtubule organizing center 9.93e-03 1.00e+00 organelle assembly 1.36e-02 1.00e+00 cilium movement 1.56e-02 1.00e+00 determination of left/right symmetry

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)