Back to main page

DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod152

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod152 Module size 79 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 27086 FOXP1 forkhead box P1 284459 HKR1 HKR1, GLI-Kruppel zinc finger family member 100506243 KRBOX1 KRAB box domain containing 1 5178 PEG3 paternally expressed 3 56979 PRDM9 PR/SET domain 9 284402 SCGB2B2 secretoglobin family 2B member 2 6668 SP2 Sp2 transcription factor 7716 VEZF1 vascular endothelial zinc finger 1 7444 VRK2 VRK serine/threonine kinase 2 404281 YY2 YY2 transcription factor 84614 ZBTB37 zinc finger and BTB domain containing 37 166793 ZBTB49 zinc finger and BTB domain containing 49 162239 ZFP1 ZFP1 zinc finger protein 124961 ZFP3 ZFP3 zinc finger protein 342357 ZKSCAN2 zinc finger with KRAB and SCAN domains 2 51351 ZNF117 zinc finger protein 117 7678 ZNF124 zinc finger protein 124 7691 ZNF132 zinc finger protein 132 7566 ZNF18 zinc finger protein 18 7567 ZNF19 zinc finger protein 19 7768 ZNF225 zinc finger protein 225 90987 ZNF251 zinc finger protein 251 56242 ZNF253 zinc finger protein 253 9534 ZNF254 zinc finger protein 254 10308 ZNF267 zinc finger protein 267 10795 ZNF268 zinc finger protein 268 10838 ZNF275 zinc finger protein 275 7576 ZNF28 zinc finger protein 28 284349 ZNF283 zinc finger protein 283 26974 ZNF285 zinc finger protein 285 57336 ZNF287 zinc finger protein 287 162979 ZNF296 zinc finger protein 296 79692 ZNF322 zinc finger protein 322 7581 ZNF33A zinc finger protein 33A 25850 ZNF345 zinc finger protein 345 163087 ZNF383 zinc finger protein 383 84124 ZNF394 zinc finger protein 394 80264 ZNF430 zinc finger protein 430 55311 ZNF444 zinc finger protein 444 92283 ZNF461 zinc finger protein 461 168544 ZNF467 zinc finger protein 467 90827 ZNF479 zinc finger protein 479 147657 ZNF480 zinc finger protein 480 90649 ZNF486 zinc finger protein 486 284443 ZNF493 zinc finger protein 493 162968 ZNF497 zinc finger protein 497 22869 ZNF510 zinc finger protein 510 85460 ZNF518B zinc finger protein 518B 84436 ZNF528 zinc finger protein 528 9745 ZNF536 zinc finger protein 536 27300 ZNF544 zinc finger protein 544 115196 ZNF554 zinc finger protein 554 148254 ZNF555 zinc finger protein 555 80032 ZNF556 zinc finger protein 556 64763 ZNF574 zinc finger protein 574 84765 ZNF577 zinc finger protein 577 147948 ZNF582 zinc finger protein 582 146434 ZNF597 zinc finger protein 597 162963 ZNF610 zinc finger protein 610 79898 ZNF613 zinc finger protein 613 253639 ZNF620 zinc finger protein 620 285268 ZNF621 zinc finger protein 621 57232 ZNF630 zinc finger protein 630 339559 ZNF642 ZFP69 zinc finger protein 55634 ZNF673 KRAB box domain containing 4 90592 ZNF700 zinc finger protein 700 441234 ZNF716 zinc finger protein 716 730087 ZNF726 zinc finger protein 726 100129543 ZNF730 zinc finger protein 730 284390 ZNF763 zinc finger protein 763 400720 ZNF772 zinc finger protein 772 7633 ZNF79 zinc finger protein 79 729648 ZNF812 zinc finger protein 812, pseudogene 730051 ZNF814 zinc finger protein 814 284371 ZNF841 zinc finger protein 841 344787 ZNF860 zinc finger protein 860 100507290 ZNF865 zinc finger protein 865 345462 ZNF879 zinc finger protein 879 7652 ZNF99 zinc finger protein 99

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

Most specific annotations for this module

Coeff.1 P-value.2 Source.3 Term.4 Class.5 1.92e-02 7.26e-41 Reactome Generic Transcription Pathway Gene expression (Transcription) 1.23e-03 7.80e-39 Reactome RNA Polymerase II Transcription Gene expression (Transcription)

¹Regression coefficient

²Fisher’s exact test nominal P-value

³Annotation source (Reactome, GO biological process (BP), molecular function (MF) and cellular component (CC))

⁴GO category or Reactome pathway

⁵High-level branch of annotation tree

Gene membership

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 2.02e-07 1.08e-04 negative regulation of transcription from RNA polymerase II promoter 2.93e-07 1.03e-04 RNA polymerase II transcription factor activity, sequence-specific DNA binding 1.95e-03 3.34e-01 meiotic gene conversion 1.95e-03 3.34e-01 gene conversion 1.95e-03 3.34e-01 regulation of interleukin-1-mediated signaling pathway 1.95e-03 3.34e-01 regulation of interleukin-12 secretion 3.89e-03 5.71e-01 positive regulation of meiosis I 3.89e-03 5.71e-01 regulation of meiosis I 3.89e-03 5.71e-01 chemokine production 3.89e-03 5.71e-01 osteoclast development 3.89e-03 5.71e-01 T follicular helper cell differentiation 3.89e-03 5.71e-01 regulation of macrophage colony-stimulating factor production 3.90e-03 5.71e-01 positive regulation of meiotic cell cycle 3.90e-03 5.71e-01 positive regulation of meiotic nuclear division 3.90e-03 5.71e-01 negative regulation of B cell apoptotic process 3.92e-03 5.00e-01 retinoic acid-responsive element binding 5.83e-03 7.72e-01 regulation of endothelial tube morphogenesis 5.84e-03 7.72e-01 regulation of defense response to bacterium 5.84e-03 7.72e-01 monocyte activation 5.84e-03 7.72e-01 regulation of interleukin-1 beta secretion

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 0.00e+00 0.00e+00 GENERIC TRANSCRIPTION PATHWAY 5.67e-03 5.07e-01 MEIOTIC RECOMBINATION 5.69e-03 5.08e-01 MEIOSIS

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Mouse mutant phenotypes

P-value1 FDR2 Term 4.57e-04 5.75e-01 decreased oocyte number 1.87e-03 1.00e+00 increased embryo size 1.87e-03 1.00e+00 atretic vasculature 3.03e-03 1.00e+00 partial lethality throughout fetal growth and development 3.74e-03 1.00e+00 mammary gland alveolar hyperplasia 3.74e-03 1.00e+00 absent maternal crouching 3.74e-03 1.00e+00 absent fibroblast proliferation 5.62e-03 1.00e+00 abnormal mammary gland growth during pregnancy 5.62e-03 1.00e+00 abnormal lymphatic vessel morphology 5.62e-03 1.00e+00 abnormal pharyngeal arch artery morphology 5.94e-03 1.00e+00 hemorrhage 7.47e-03 1.00e+00 abnormal germ cell morphology 7.47e-03 1.00e+00 abnormal meiosis 9.33e-03 1.00e+00 abnormal mammary gland physiology 9.37e-03 1.00e+00 abnormal mammary gland morphology 9.65e-03 1.00e+00 small testis 1.12e-02 1.00e+00 abnormal chromosome pairing during meiosis 1.12e-02 1.00e+00 abnormal imprinting 1.12e-02 1.00e+00 abnormal pup retrieval 1.30e-02 1.00e+00 maternal imprinting

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)