Back to main page

DREAM Module Identification Challenge – Consensus modules

PPI-STRING_Consensus_mod110

Assigned name NA Network PPI-STRING Module ID PPI-STRING_Consensus_mod110 Module size 63 genes

Module genes

This module comprises the following genes:

Gene ID Gene Symbol Gene Name 339416 ANKRD45 ankyrin repeat domain 45 51501 C11orf73 Hikeshi, heat shock protein nuclear import factor 548596 CKMT1A creatine kinase, mitochondrial 1A 1159 CKMT1B creatine kinase, mitochondrial 1B 81570 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 3301 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 10294 DNAJA2 DnaJ heat shock protein family (Hsp40) member A2 9093 DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 55466 DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 3337 DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 51726 DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 54788 DNAJB12 DnaJ heat shock protein family (Hsp40) member B12 374407 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 79982 DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 3300 DNAJB2 DnaJ heat shock protein family (Hsp40) member B2 11080 DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 25822 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 10049 DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 150353 DNAJB7 DnaJ heat shock protein family (Hsp40) member B7 165721 DNAJB8 DnaJ heat shock protein family (Hsp40) member B8 4189 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 64215 DNAJC1 DnaJ heat shock protein family (Hsp40) member C1 55735 DNAJC11 DnaJ heat shock protein family (Hsp40) member C11 56521 DNAJC12 DnaJ heat shock protein family (Hsp40) member C12 29103 DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 23341 DNAJC16 DnaJ heat shock protein family (Hsp40) member C16 55192 DNAJC17 DnaJ heat shock protein family (Hsp40) member C17 202052 DNAJC18 DnaJ heat shock protein family (Hsp40) member C18 79962 DNAJC22 DnaJ heat shock protein family (Hsp40) member C22 120526 DNAJC24 DnaJ heat shock protein family (Hsp40) member C24 548645 DNAJC25 DnaJ heat shock protein family (Hsp40) member C25 552891 DNAJC25-GNG10 DNAJC25-GNG10 readthrough 5611 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 84277 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 3338 DNAJC4 DnaJ heat shock protein family (Hsp40) member C4 80331 DNAJC5 DnaJ heat shock protein family (Hsp40) member C5 85479 DNAJC5B DnaJ heat shock protein family (Hsp40) member C5 beta 285126 DNAJC5G DnaJ heat shock protein family (Hsp40) member C5 gamma 7266 DNAJC7 DnaJ heat shock protein family (Hsp40) member C7 23234 DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 728489 DNLZ DNL-type zinc finger 2272 FHIT fragile histidine triad 80273 GRPEL1 GrpE like 1, mitochondrial 134266 GRPEL2 GrpE like 2, mitochondrial 84681 HINT2 histidine triad nucleotide binding protein 2 259217 HSPA12A heat shock protein family A (Hsp70) member 12A 116835 HSPA12B heat shock protein family A (Hsp70) member 12B 6782 HSPA13 heat shock protein family A (Hsp70) member 13 51182 HSPA14 heat shock protein family A (Hsp70) member 14 3303 HSPA1A heat shock protein family A (Hsp70) member 1A 3304 HSPA1B heat shock protein family A (Hsp70) member 1B 3305 HSPA1L heat shock protein family A (Hsp70) member 1 like 3306 HSPA2 heat shock protein family A (Hsp70) member 2 3308 HSPA4 heat shock protein family A (Hsp70) member 4 22824 HSPA4L heat shock protein family A (Hsp70) member 4 like 3309 HSPA5 heat shock protein family A (Hsp70) member 5 3310 HSPA6 heat shock protein family A (Hsp70) member 6 3313 HSPA9 heat shock protein family A (Hsp70) member 9 10808 HSPH1 heat shock protein family H (Hsp110) member 1 10525 HYOU1 hypoxia up-regulated 1 503497 MS4A13 membrane spanning 4-domains A13 55316 RSAD1 radical S-adenosyl methionine domain containing 1 54059 YBEY ybeY metalloendoribonuclease

Functional annotation

Modules were tested for enrichment in functional and pathway annotations using two complementary approaches:
1. To select a small number of specific / non-redundant annotations for each module, a regression-based approach was used;
2. To obtain the complete set of enriched annotations, an extension of Fisher’s exact test that takes annotation bias into account was employed (Wallenius’ non-central hypergeometric distribution).

Most specific annotations for this module

Coeff.1 P-value.2 Source.3 Term.4 Class.5 2.90e-01 2.12e-19 GO negative regulation of inclusion body assembly biological_process 2.28e-01 3.03e-36 GO chaperone cofactor-dependent protein refolding biological_process 9.98e-02 1.63e-19 GO ATPase activator activity molecular_function 9.26e-02 1.70e-34 GO response to unfolded protein biological_process 6.77e-02 1.05e-22 GO misfolded protein binding molecular_function 6.56e-02 2.57e-25 GO protein refolding biological_process 6.56e-02 2.39e-07 GO protein import into mitochondrial matrix biological_process 6.49e-02 6.41e-20 GO positive regulation of ATPase activity biological_process 4.54e-02 5.45e-41 GO unfolded protein binding molecular_function 4.22e-02 4.61e-32 GO chaperone binding molecular_function 2.82e-02 1.05e-27 Reactome Regulation of HSF1-mediated heat shock response Cellular responses to external stimuli 1.06e-03 2.84e-23 GO heat shock protein binding molecular_function 2.21e-04 5.91e-07 GO IRE1-mediated unfolded protein response biological_process

¹Regression coefficient

²Fisher’s exact test nominal P-value

³Annotation source (Reactome, GO biological process (BP), molecular function (MF) and cellular component (CC))

⁴GO category or Reactome pathway

⁵High-level branch of annotation tree

Gene membership

All enriched annotations

Gene Ontology

P-value1 FDR2 Term 0.00e+00 0.00e+00 protein folding 0.00e+00 0.00e+00 protein refolding 0.00e+00 0.00e+00 response to heat 0.00e+00 0.00e+00 response to temperature stimulus 0.00e+00 0.00e+00 regulation of inclusion body assembly 0.00e+00 0.00e+00 negative regulation of inclusion body assembly 0.00e+00 0.00e+00 response to unfolded protein 0.00e+00 0.00e+00 positive regulation of ATPase activity 0.00e+00 0.00e+00 regulation of ATPase activity 0.00e+00 0.00e+00 heat shock protein binding 0.00e+00 0.00e+00 unfolded protein binding 0.00e+00 0.00e+00 chaperone binding 0.00e+00 0.00e+00 ATPase regulator activity 0.00e+00 0.00e+00 ATPase activator activity 8.23e-10 6.19e-07 regulation of cellular response to heat 5.49e-08 3.23e-05 chaperone-mediated protein folding 1.51e-07 8.27e-05 cellular heat acclimation 2.46e-07 1.30e-04 regulation of cellular response to stress 4.71e-07 1.58e-04 C3HC4-type RING finger domain binding 5.16e-07 2.59e-04 IRE1-mediated unfolded protein response

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Reactome

P-value1 FDR2 Term 5.08e-07 9.28e-05 UNFOLDED PROTEIN RESPONSE 1.02e-06 2.31e-04 UNFOLDED PROTEIN RESPONSE 2.56e-06 4.17e-04 DIABETES PATHWAYS 5.65e-06 8.80e-04 ACTIVATION OF CHAPERONE GENES BY XBP1S 5.99e-06 1.19e-03 ACTIVATION OF CHAPERONE GENES BY XBP1S 1.17e-05 2.21e-03 DIABETES PATHWAYS 1.52e-04 2.26e-02 MITOCHONDRIAL PROTEIN IMPORT 3.89e-03 3.32e-01 MITOCHONDRIAL PROTEIN IMPORT 5.27e-03 4.29e-01 INFLUENZA LIFE CYCLE 8.90e-03 6.68e-01 DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 1.03e-02 8.15e-01 DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 1.11e-02 8.65e-01 INFLUENZA LIFE CYCLE 1.88e-02 1.00e+00 ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA 2.06e-02 1.00e+00 GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 2.15e-02 1.00e+00 ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA 2.72e-02 1.00e+00 ACTIVATION OF CHAPERONES BY ATF6 ALPHA 2.80e-02 1.00e+00 ACTIVATION OF CHAPERONES BY ATF6 ALPHA 2.82e-02 1.00e+00 ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 3.09e-02 1.00e+00 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 3.24e-02 1.00e+00 GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)

Mouse mutant phenotypes

P-value1 FDR2 Term 3.34e-04 4.78e-01 increased defecation amount 4.60e-04 5.77e-01 decreased startle reflex 4.91e-04 6.00e-01 abnormal hearing physiology 7.55e-04 7.64e-01 decreased grooming behavior 1.02e-03 9.10e-01 abnormal prepulse inhibition 1.82e-03 1.00e+00 abnormal pancreatic beta cell morphology 1.87e-03 1.00e+00 abnormal cortical intermediate zone morphology 1.87e-03 1.00e+00 abnormal otoacoustic response 3.75e-03 1.00e+00 abnormal Clara cell morphology 5.09e-03 1.00e+00 asthenozoospermia 5.17e-03 1.00e+00 increased sensitivity to induced cell death 5.61e-03 1.00e+00 abnormal alveolar lamellar body morphology 7.03e-03 1.00e+00 abnormal spermatocyte morphology 7.48e-03 1.00e+00 abnormal substantia nigra pars compacta morphology 8.41e-03 1.00e+00 oligozoospermia 9.34e-03 1.00e+00 decreased surfactant secretion 1.12e-02 1.00e+00 increased cell death 1.12e-02 1.00e+00 decreased exploration in new environment 1.31e-02 1.00e+00 abnormal grip strength 1.67e-02 1.00e+00 tau protein deposits

¹1Nominal enrichment p-value (Wallenius’ noncentral hypergeometric distribution)

²FDR corrected p-value (Benjamini-Hochberg)